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508839 Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem

A cell-permeable, selective, highly potent, non-nucleotide competitive inhibitor of telomerase activity (IC₅₀ = 93 nM in HeLa cells nuclear extracts).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BIBR 1532, BIBR-1532

Primary Target: Teomerase
508839
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
321674-73-1C₂₁H₁₇NO₃

Products

Catalogue NumberPackaging Qty/Pack
5088390001 Glass bottle 10 mg
Description
OverviewA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508839
Brand Family Calbiochem®
SynonymsBIBR 1532, BIBR-1532
References
ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
Product Information
CAS number321674-73-1
FormOff-white solid
Hill FormulaC₂₁H₁₇NO₃
Chemical formulaC₂₁H₁₇NO₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetTeomerase
Primary Target IC<sub>50</sub>93 nM
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5088390001 04055977261424

Documentation

Telomerase Inhibitor X, BIBR1532 - CAS 321674-73-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Damm, K., et al. 2001. The. EMBO J. 20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-March-2014 JSW
SynonymsBIBR 1532, BIBR-1532
DescriptionA cell-permeable benzoic acid based compound that acts as a selective, highly potent, non-nucleotide competitive inhibitor of the catalytic activity of telomerase (IC50 = 93 nM in HeLa cells nuclear extracts). Also shown to be effective against recombinant, affinity purified telomerase. Blocks the growth and proliferation of HeLa cells (~ 20 µM) by inducing apoptosis. The inhibition appears to be more prominent in TEL patch mutant cell lines. Causes a continuous erosion of telomeres in multiple human cancer cell lines. Does not affect the activity of DNA and RNA polymerases in any significant manner.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number321674-73-1
Chemical formulaC₂₁H₁₇NO₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDamm, K., et al. 2001. The. EMBO J. 20, 6958.
Pascolo, E., et al. 2002. J. Biol. Chem. 277,15566.
Nakashima, M., et al. 2013. J. Biol. Chem. 288, 33171.