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506600 Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem

A potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate

Primary Target: Inhibitor of bone resorption
506600
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
109552-15-0C₃H₉NO₇P₂·2Na·5H₂O

Products

Catalogue NumberPackaging Qty/Pack
506600-10MG Plastic ampoule 10 mg
Description
OverviewA potent and specific inhibitor of bone resorption that does not cause any significant detrimental effect on bone growth and mineralization at concentrations used. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget’s disease, hypercalcaemia of malignancy, osteolytic bone metastasis, steroid-induced osteoporosis, and idiopathic osteoporosis. Inhibits breast cancer cell growth by inducing cell death in vitro. Provided in hydrated form, contains five molecules of water.
Catalogue Number506600
Brand Family Calbiochem®
Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
References
ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
Product Information
CAS number109552-15-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃H₉NO₇P₂·2Na·5H₂O
Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInhibitor of bone resorption
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSSZ6522666
Safety Information
R PhraseR: 20/21/22-61

Harmful by inhalation, in contact with skin and if swallowed.
May cause harm to the unborn child.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506600-10MG 04055977272482

Documentation

Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Pamidronate, Disodium Salt - CAS 109552-15-0 - Calbiochem Certificates of Analysis

TitleLot Number
506600

References

Reference overview
Fromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs 41, 289.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-May-2008 RFH
Synonyms3-Amino-1-hydroxypropylidene-bisphosphonic Acid, 2Na, Pentahydrate
DescriptionA calcium metabolism regulator. A potent and specific inhibitor of bone resorption at doses devoid of any significant detrimental effect on bone growth and mineralization. Effective in a variety of conditions characterized by pathologically enhanced bone turnover, including Paget's disease, hypercalcemia of malignancy, osteolytic bone metastasis, and steroid-induced cell death in vitro. Provided in a hydrated form containing five molecules of water.
FormWhite solid
CAS number109552-15-0
RTECSSZ6522666
Chemical formulaC₃H₉NO₇P₂·2Na·5H₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityH₂O (10 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 6 months at 4°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14, 7003
ReferencesFromigue, O., et al. 2000. J. Bone Miner. Res. 15, 2211.
Fitton, A., and McTravish, D. 1991. Drugs 41, 289.