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492905 Nucleozin - CAS 341001-38-5 - Calbiochem

A cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells.

Nucleozin - CAS 341001-38-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
492905
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
341001-38-5C₂₁H₁₉ClN₄O₄

Products

Catalogue NumberPackaging Qty/Pack
492905-25MG Glass bottle 25 mg
Description
OverviewA cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.
Catalogue Number492905
Brand Family Calbiochem®
References
ReferencesKao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.
Product Information
CAS number341001-38-5
FormYellow powder
Hill FormulaC₂₁H₁₉ClN₄O₄
Chemical formulaC₂₁H₁₉ClN₄O₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
492905-25MG 04055977272802

Documentation

Nucleozin - CAS 341001-38-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nucleozin - CAS 341001-38-5 - Calbiochem Certificates of Analysis

TitleLot Number
492905

References

Reference overview
Kao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2011 RFH
DescriptionA cell-permeable isoxazolylpiperazine compound that is shown to inhibit influenza A H1N1 (A/WSN/33 strain), H3N2 (clinical isolate), and H5N1 (A/Vietnam/1194/04) replication in MDCK cells in vitro (EC50 = 69, 160, and 330 nM, respectively) and significantly reduce fatality after A/Vietnam/1194/04 infection in mice in vivo (50% survial rate on day 21 with 14 b.i.d. i.p. doses of 230 µg/mouse in the first 7 days after infection) by preventing nucleoprotein (NP) nuclear accumulation via NP aggregation induction during early stages of viral infection. Virus strains with N309K or Y289H NP mutation, such as swine-origin influenza A (S-OIV) H1N1, are found to be resistant to Nucleozin, consistent with the N309-mediated hydrogen bonding and Y289-mediated hydrophobic interaction with Nucleozin as predicted by computer-aided docking studies.
FormYellow powder
CAS number341001-38-5
Chemical formulaC₂₁H₁₉ClN₄O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesKao, R.Y., et al. 2010. Nat. Biotechnol. 28, 600.