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481984 Nifuroxazide - CAS 965-52-6 - Calbiochem

A cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity.

Nifuroxazide - CAS 965-52-6 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone

481984
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
965-52-6C₁₂H₉N₃O₅

Products

Catalogue NumberPackaging Qty/Pack
481984-500MG Plastic ampoule 500 mg
Description
OverviewA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
Catalogue Number481984
Brand Family Calbiochem®
Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
References
ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.
Product Information
CAS number965-52-6
FormBright yellow solid
Hill FormulaC₁₂H₉N₃O₅
Chemical formulaC₁₂H₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
481984-500MG 04055977183450

Documentation

Nifuroxazide - CAS 965-52-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Nifuroxazide - CAS 965-52-6 - Calbiochem Certificates of Analysis

TitleLot Number
481984

References

Reference overview
Nelson, E.A., et al. 2008. Blood 112, 5095.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-April-2009 RFH
Synonyms5-Nitro-2-furaldehyde-p-hydroxybenzoylhydrazone
DescriptionA cell-permeable and orally available nitrofuran-based antidiarrheal agent that effectively suppresses the activation of cellular STAT1/3/5 transcription activity (IC50 = 3 µM against IL-6-induced STAT3 activation in U3A cells), while exhibiting little effect against TNF-α-induced NF-κB activation in 293 cells. Shown to inhibit cellular tyrosine phosphorylations of JAK2/TYK2/STAT3 (IC50 = 10 µM against tyr705 of STAT3 in U266 cells), but not those of Akt/EGFR/JAK1/MAPK/Src or the ser727 phosphorylation of STAT3.
FormBright yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number965-52-6
Chemical formulaC₁₂H₉N₃O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesNelson, E.A., et al. 2008. Blood 112, 5095.