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492031 NS8593 - CAS 875755-39-8 - Calbiochem

An aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels in a Ca2+-dependent manner.

NS8593 - CAS 875755-39-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine

492031
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
875755-39-8C₁₇H₁₇N₃

Products

Catalogue NumberPackaging Qty/Pack
492031-10MG Glass bottle 10 mg
Description
OverviewAn aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; Kd = 420 nM, 600 nM, and 730 nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50 = 1.6 mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture.
Catalogue Number492031
Brand Family Calbiochem®
Synonyms(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine
References
ReferencesChubanov, V., et al. 2012. Brit. Journ. Pharm. 166, 1357.
Jenkins, D., et al. 2011. Hypertension. 57, 1129.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Lasse, S., et al. 2011. J. Cardiov. Pharm. 57, 672.
Diness, J., et al. 2010. Circ Arrhythm Electrophusiol. 3, 380.
Ji, H., et al. 2009. Eur. J. Neurosci. 9, 1883.
Strobaek, D., et al. 2006. Mol. Pharm. 70, 1771.
Product Information
CAS number875755-39-8
FormWhite powder
Hill FormulaC₁₇H₁₇N₃
Chemical formulaC₁₇H₁₇N₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
492031-10MG 04055977273564

Documentation

NS8593 - CAS 875755-39-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

NS8593 - CAS 875755-39-8 - Calbiochem Certificates of Analysis

TitleLot Number
492031

References

Reference overview
Chubanov, V., et al. 2012. Brit. Journ. Pharm. 166, 1357.
Jenkins, D., et al. 2011. Hypertension. 57, 1129.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Lasse, S., et al. 2011. J. Cardiov. Pharm. 57, 672.
Diness, J., et al. 2010. Circ Arrhythm Electrophusiol. 3, 380.
Ji, H., et al. 2009. Eur. J. Neurosci. 9, 1883.
Strobaek, D., et al. 2006. Mol. Pharm. 70, 1771.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-August-2012 JSW
Synonyms(R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine
DescriptionAn aminobenzimidazole derivative that selectively and reversibly blocks small conductance Ca2+-activated K+ channels (SK1-3; Kd = 420 nM, 600 nM, and 730 nM for SK1, SK2, SK3, respectively) in a Ca2+-dependent manner. It mediates channel gating by interacting with gating structures deep within the inner pore vestibule where Ser507 and Ala532 are deemed to be important for inhibition. Interacts at a site that is distinct from the apamin binding site in SK channels. Can access high-affinity binding sites from both the inside and outside of the cell membrane. Does not affect QT intervals, but prolongs the atrial effective refractive period and prevents acetylcholine-induced atrial fibrillations in ex vivo and in vivo models. Also shown to reversibly block TRPM7 channel (IC50 = 1.6 mM) in smooth muscle cells, primary podocytes, HEK293 cells expressing TRPM7, and ventricular myocytes in a Mg2+-dependent manner and blocks the motility of cells in culture.
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
CAS number875755-39-8
Chemical formulaC₁₇H₁₇N₃
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesChubanov, V., et al. 2012. Brit. Journ. Pharm. 166, 1357.
Jenkins, D., et al. 2011. Hypertension. 57, 1129.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Jenkins, D., et al. 2011. Mol. Pharm. 79, 899.
Lasse, S., et al. 2011. J. Cardiov. Pharm. 57, 672.
Diness, J., et al. 2010. Circ Arrhythm Electrophusiol. 3, 380.
Ji, H., et al. 2009. Eur. J. Neurosci. 9, 1883.
Strobaek, D., et al. 2006. Mol. Pharm. 70, 1771.