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475913 Mycophenolic Acid - CAS 24280-93-1 - Calbiochem

An immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA

Primary Target: Inosine monophosphate dehydrogenase
475913
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
24280-93-1C₁₇H₂₀O₆

Products

Catalogue NumberPackaging Qty/Pack
475913-100MG Plastic ampoule 100 mg
475913-500MG Plastic ampoule 500 mg
Description
OverviewAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of inosine monophosphate dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
Catalogue Number475913
Brand Family Calbiochem®
Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
References
ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation 60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
Product Information
CAS number24280-93-1
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₁₇H₂₀O₆
Chemical formulaC₁₇H₂₀O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetInosine monophosphate dehydrogenase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSMP8050000
Safety Information
R PhraseR: 20/21/22-40

Harmful by inhalation, in contact with skin and if swallowed.
Limited evidence of a carcinogenic effect.
S PhraseS: 22-36

Do not breathe dust.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage +15°C to +30°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475913-100MG 04055977184822
475913-500MG 04055977184150

Documentation

Mycophenolic Acid - CAS 24280-93-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Mycophenolic Acid - CAS 24280-93-1 - Calbiochem Certificates of Analysis

TitleLot Number
475913

References

Reference overview
Langman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation 60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-May-2008 RFH
Synonyms6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-hexenoic Acid, MPA
DescriptionAn immunosuppressive agent that inhibits de novo purine nucleotide synthesis via inhibition of IMP dehydrogenase and prevents the formation of XMP and GMP. Useful for selection of animal cells that express the E. coli gene coding for xanthine-guanine phosphoribosyltransferase. Also suppresses cytokine-induced nitric oxide production in mouse and rat vascular endothelial cells.
FormWhite to off-white solid
CAS number24280-93-1
RTECSMP8050000
Chemical formulaC₁₇H₂₀O₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityEthanol or 100 mM NaOH (10 mg/ml)
Storage +15°C to +30°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, sterilize by filtration through a 0.22 µm pore-size filter, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Harmful & Carcinogenic / Teratogenic
Merck USA index14 6327
ReferencesLangman, L.J., et al. 1995. Clin. Chem. 41, 295.
Senda, M., et al. 1995. Transplantation 60, 1143.
Warner-Bartnicki, A.L., et al. 1993. Exp. Cell Res. 204, 241.
Falkner, F.G., and Moss, B. 1988. J. Virol. 62, 1849.
Cohen, M.B., et al. 1981. J. Biol. Chem. 256, 8713.
Mulligan, R.C., and Berg, P. 1981. Proc. Natl. Acad. Sci. USA 78, 2072.