373227 Sigma-AldrichMDM2 Inhibitor VII, MEL23 - CAS 642072-49-9 - Calbiochem
The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.
More>> The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: MDM2-MDMX E3 Ligase Inhibitor, 3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione
Recommended Products
Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 642072-49-9 | C₁₉H₂₂N₄O₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 373227-10MG | Glass bottle | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable tetrahydro-β-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100 µM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc. = 14 µM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3 (Cat. Nos. 444143 & 444151), MEL23 does not interfere with Mdm2-p53 interaction. |
| Catalogue Number | 373227 |
| Brand Family | Calbiochem® |
| Synonyms | MDM2-MDMX E3 Ligase Inhibitor, 3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione |
| References | |
|---|---|
| References | Herman, A.G., et al. 2011. Cancer Discovery 1, 312. |
| Product Information | |
|---|---|
| CAS number | 642072-49-9 |
| Form | Yellow solid |
| Hill Formula | C₁₉H₂₂N₄O₃ |
| Chemical formula | C₁₉H₂₂N₄O₃ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 373227-10MG | 04055977190991 |