400600 Sigma-AldrichL-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem
A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA.
More>> A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase compared to other arginine analogs such as L-NAME and L-NMMA. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: L-NIO, 2HCl
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 159190-44-0 | C₇H₁₅N₃O₂ · 2HCl |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 400600-20MG | Plastic ampoule | 20 mg |
| Description | |
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| Overview | A cell-permeable, more potent inhibitor of endothelial nitric oxide synthase (eNOS; IC50 = 500 nM) compared to other arginine analogs such as L-NAME (Cat. No. 483125) and L-NMMA (Cat. No. 475886). Inhibits acetylcholine-induced relaxation of rat aorta rings (IC50 = 2 µM) and causes a dose-dependent increase in mean arterial blood pressure in the rat (EC50 = 19.5 mg/kg). |
| Catalogue Number | 400600 |
| Brand Family | Calbiochem® |
| Synonyms | L-NIO, 2HCl |
| References | |
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| References | Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746. |
| Product Information | |
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| CAS number | 159190-44-0 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₇H₁₅N₃O₂ · 2HCl |
| Chemical formula | C₇H₁₅N₃O₂ · 2HCl |
| Hygroscopic | Hygroscopic |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 400600-20MG | 04055977189346 |
Documentation
L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem SDS
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L-N⁵-(1-Iminoethyl)ornithine, Dihydrochloride - CAS 159190-44-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 400600 |
References
| Reference overview |
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| Moore, W.M., et al. 1994. J. Med. Chem. 37, 3886. Rees, D.D., et al. 1990. Br. J. Pharmacol. 101, 746. |
Brochure
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| Pathways and Biomarkers of Oxidative Stress |