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565784 InSolution™ γ-Secretase Inhibitor IX - Calbiochem

InSolution™ g-Secretase Inhibitor IX, CAS 208255-80-5, is a 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of g-secretase Inhibitor IX (DAPT; Cat. No. 565770) in DMSO.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT

Primary Target: Aβtotal
565784
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₂₃H₂₆F₂N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
565784-10MG Plastic ampoule 10 mg
565784-5MG Glass bottle 5 mg
Description
Catalogue Number565784
Brand Family Calbiochem®
SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
References
ReferencesOddo, S., et al. 2004. Neuron 43, 321.
Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
Product Information
ATP CompetitiveN
FormClear colorless liquid
FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
Hill FormulaC₂₃H₂₆F₂N₂O₄
Chemical formulaC₂₃H₂₆F₂N₂O₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetAβtotal
Primary Target IC<sub>50</sub>115 nM, 200 nM against Aβtotal, Aβ42, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
565784-10MG 04055977267303
565784-5MG 04055977191806

Documentation

InSolution™ γ-Secretase Inhibitor IX - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

InSolution™ γ-Secretase Inhibitor IX - Calbiochem Certificates of Analysis

TitleLot Number
565784

References

Reference overview
Oddo, S., et al. 2004. Neuron 43, 321.
Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.

Citations

Title
  • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
  • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
  • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
    		•
    Data Sheet

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-January-2013 JSW
    SynonymsN-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester, DAPT
    DescriptionA cell-permeable dipeptide that inhibits γ-secretase activity and suppresses Aβ production (Aβ total IC50 = 115 nM; Aβ42 IC50 = 200 nM). Reported to be functionally active in both HEK293 cells overexpressing human APP751 and neuronal cultures, however, it does not affect the secretion of amyloid-b precursor protein (APP). Effective in acutely lowering Ab in APPV717F-transgenic mice. Also effective in inhibiting the production of a ~6 kDa C-terminal cleavage product (CTFg) in HEK293 cells stably transfected with the Swedish mutant, βAPP695. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice.
    FormClear colorless liquid
    FormulationA 25 mM (5 mg/462 µl or 10 mg/924 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565770) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₂₃H₂₆F₂N₂O₄
    Structure formulaStructure formula
    Purity≥95% by HPLC
    Storage Protect from light
    +2°C to +8°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial use, aliquot and freeze (-20°C).
    Toxicity Irritant
    ReferencesOddo, S., et al. 2004. Neuron 43, 321.
    Dovey, H.F., et al. 2001. J. Neurochem. 76, 173.
    Vandermeeren, M., et al. 2001. Neurosci. Lett. 315, 145.
    Citation
  • Yunzhou Dong, et al. (2006) Calpain inhibitor MDL28170 modulates Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation. FASEB Journal in press,.
  • Yasuhiko Kawakami, et al. (2005) Retinoic acid signalling links leftright asymmetric patterning and bilaterally symmetric somitogenesis in the zebrafish embryo. Nature 435, 165-171.
  • Aurelie Olivier, et al. (2005) The Notch ligand delta-1 is a hematopoietic development co- factor for plasmacytoid dendritic cells. Blood 107, 2694-2701.
    		•