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401105 Importazole - CAS 662163-81-7 - Calbiochem

A cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS bearing cargos in a reversible manner.

Importazole - CAS 662163-81-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(1-Phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine, IPZ, Importin-β Inhibitor

401105
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
662163-81-7C₂₀H₂₂N₄

Products

Catalogue NumberPackaging Qty/Pack
401105-10MG Glass bottle 10 mg
Description
OverviewA cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC50 = 15 µM against Ca+2-induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export.
Catalogue Number401105
Brand Family Calbiochem®
SynonymsN-(1-Phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine, IPZ, Importin-β Inhibitor
References
ReferencesSoderholm, J.F., et al. 2011. ACS Chem. Biol. 6, 700.
Product Information
CAS number662163-81-7
FormWhite solid
Hill FormulaC₂₀H₂₂N₄
Chemical formulaC₂₀H₂₂N₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
401105-10MG 04055977189476

Documentation

Importazole - CAS 662163-81-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Importazole - CAS 662163-81-7 - Calbiochem Certificates of Analysis

TitleLot Number
401105

References

Reference overview
Soderholm, J.F., et al. 2011. ACS Chem. Biol. 6, 700.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-September-2012 JSW
SynonymsN-(1-Phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine, IPZ, Importin-β Inhibitor
DescriptionA cell-permeable diaminoquinazoline compound that selectively blocks importin-β-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC50 = 15 µM against Ca+2-induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export. IPZ affects, but not blocks, importin-β-RanGTP interaction, likely by inducing a conformational change upon direct importin-β binding. IPZ treatment impairs cellular mitosis and is cytotoxic to HeLa cells (50% and >90% killing in 24 h, respectively, with 22.5 and 60 µM IPZ).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number662163-81-7
Chemical formulaC₂₀H₂₂N₄
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml; clear, colorless solution)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSoderholm, J.F., et al. 2011. ACS Chem. Biol. 6, 700.