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14-1067 Human Recombinant MeCP2 (methyl-CpG-binding protein 2)

Human recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells & purified by Fast Protein Liquid Chromatography (FPLC) & demonstrated to bind methylated DNA

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: DNA-binding Proteins
14-1067
10 µg  
Purchase on Sigma-Aldrich

Overview

Description
Catalogue Number14-1067
DescriptionHuman Recombinant MeCP2 (methyl-CpG-binding protein 2)
OverviewHuman recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells and purified by Fast Protein Liquid Chromatography (FPLC).
Background InformationMeCP2 (methyl-CpG-binding protein 2) binds methylated CpG sequences in double-stranded DNA resulting in the suppression of transcription. This protein is likely to be involved in the repression of multiple genes. Consistent with this role, mutations of MeCP2 are linked to Rett syndrome, a progressive neurological disorder that is one of the most common causes of mental retardation in females.
Product Information
PresentationIn a buffer containing 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 M NaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT.
Quality LevelMQ100
Applications
ApplicationHuman recombinant N-terminal His-tagged MeCP2 expressed in SF9 insect cells & purified by Fast Protein Liquid Chromatography (FPLC) & demonstrated to bind methylated DNA
Key Applications
  • DNA-binding Proteins
Biological Information
Concentration0.5 µg/µL
PurityGreater than 95% purity by SDS PAGE
Molecular Weight50.2 kDa including histidine tag
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable at -80ºC for 6 months from date of receipt.
Packaging Information
Material Size10 µg
Global Trade Item Number
Catalogue Number GTIN
14-1067 04053252957437