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371724 GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem

The GPR119 Agonist, AS1269574, also referenced under CAS 330981-72-1, controls the biological activity of GPR119. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist

371724
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
330981-72-1C₁₃H₁₄BrN₃O

Products

Catalogue NumberPackaging Qty/Pack
371724-10MG Glass bottle 10 mg
Description
OverviewA pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.44 and 0.22, respectively, with or without 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (100 mg/kg; p.o.) without any significant hypoglycemic effect in vivo.
Catalogue Number371724
Brand Family Calbiochem®
Synonyms2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
References
ReferencesYoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.
Product Information
CAS number330981-72-1
FormAmber solid
Hill FormulaC₁₃H₁₄BrN₃O
Chemical formulaC₁₃H₁₄BrN₃O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
371724-10MG 04055977213263

Documentation

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GPR119 Agonist, AS1269574 - CAS 330981-72-1 - Calbiochem Certificates of Analysis

TitleLot Number
371724

References

Reference overview
Yoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-September-2012 JSW
Synonyms2-((2-(4-Bromophenyl)-6-methylpyrimidin-4-yl)amino)ethanol, G-Protein Coupled Receptor 119 Agonist, GPCR2 Agonist, MGC119957 Agonist, SNORF25 Agonist
DescriptionA pyrimidine compound that acts as an effective GPR119 agonist (EC50 = 2.5 µM in stimulating cAMP in hGPR119-expressing HEK293 cells) and reportedly exhibits no activity toward β-adrenergic or GLP-1 receptors. Shown to enhance 16.8 mM glucose-induced insulin secretion from murine MIN-6 β-cells (mU/20 min = 0.22, 0.29, 0.44, respectively, with 0, 1, 10 µM AS1269574) in vitro and improve glucose tolerance in normal mice (26% decrease and 60% increase, respectively, of control blood glucose and insulin AUC0-1h in OGTT; 100 mg/kg; p.o.) without affecting basal blood glucose level in either fed or fasting mice in vivo.
FormAmber solid
Intert gas (Yes/No) Packaged under inert gas
CAS number330981-72-1
Chemical formulaC₁₃H₁₄BrN₃O
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (>10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesYoshida, S., et cl. 2010. Biochem. Biophys. Res. Commun. 400, 437.