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GF303 G-CSF Protein, Human Recombinant Animal Free

The GCSF protein is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation & activation of hematopoietic cells of the neutrophilic granulocyte lineage. Manufactured using all non-animal reagents.

G-CSF Protein, Human Recombinant Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P09919 Entrez Gene Number: NM_000759.42, NM_172219.1, NM_172220.1
GF303
10 µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
E. coli Product is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
Description
Catalogue NumberGF303
DescriptionG-CSF Protein, Human Recombinant Animal Free
Alternate Names
  • GCSF
  • Granulocyte Colony Stimulating Factor
  • Pluripoietin
  • Filgrastim
  • Lenograstim
Background InformationGranulocyte Colony-Stimulating Factor (GCSF) is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation, and activation of hematopoietic cells of the neutrophilic granulocyte lineage. It is produced mainly by monocytes and macrophages upon activation by endotoxin, TNFα and IFNγ. Other cell types including fibroblasts endothelial cells, astrocytes and bone marrow stromal cells can also secrete GCSF after LPS, IL1 or TNFα activation. In addition, various carcinoma cell lines and myeloblastic leukemia cells can express GCSF constitutively. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant human G-CSF is an 18.7 kDa protein consisting of 174 amino acid residues.
References
Product Information
Formulation
PresentationProduct is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
ApplicationThe GCSF protein is a pleiotropic cytokine best known for its specific effects on the proliferation, differentiation & activation of hematopoietic cells of the neutrophilic granulocyte lineage. Manufactured using all non-animal reagents.
Biological Information
PurityProduct is endotoxin free (< 0.1ng/μg of protein (<1EU/μg) and greater than 98% pure by SDS-PAGE gel and HPLC analyses
SourceE. coli
Cross ReactivityMouse
Entrez Gene Number
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceBioactivity assay: Determined by its ability to stimulate the proliferation of mouse M-NFS-60 cells. The expected ED50 is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 6 months from date of receipt.
Packaging Information
Material Size10 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF303 04053252691447

Documentation

G-CSF Protein, Human Recombinant Animal Free SDS

Title

Safety Data Sheet (SDS) 

G-CSF Protein, Human Recombinant Animal Free Certificates of Analysis

TitleLot Number
Recombinant Animal Free Human G-CSF - 3428706 3428706
Recombinant Animal Free Human G-CSF - 3448962 3448962
Recombinant Animal Free Human G-CSF - 3463630 3463630
Recombinant Animal Free Human G-CSF - 3465954 3465954
Recombinant Animal Free Human G-CSF - 3485505 3485505
Recombinant Animal Free Human G-CSF - 3492228 3492228
Recombinant Animal Free Human G-CSF - 3583874 3583874
Recombinant Animal Free Human G-CSF - 3719591 3719591
Recombinant Animal Free Human G-CSF - 3816376 3816376
Recombinant Animal Free Human G-CSF - 3868400 3868400
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Brochure

Title
New Products: Volume 3, 2012

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Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors