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344931 Furin Inhibitor II - Calbiochem

344931
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Overview

Key Spec Table

Empirical Formula
C₃₆H₇₅N₂₅O₆

Products

Catalogue NumberPackaging Qty/Pack
344931-1MG Plastic ampoule 1 mg
Description
OverviewA polyarginine compound that acts as a potent, specific, and competitive inhibitor of furin (Ki = 106 nM). Inhibits Subtilisin-like proprotein convertase 4 (PACE4) and prohormone convertase 1 (PC1) at much higher concentration (Ki = 580 nM and 13 µM, respectively). Has a stimulatory effect on the activity of prohormone convertase 2 (PC2). The D-peptides are suggested to be more resistant to in vivo hydrolysis than L-peptides.
Catalogue Number344931
Brand Family Calbiochem®
SynonymsHexa-D-arginine, H-(D)RRRRRR-NH₂
References
ReferencesCameron, A., et al. 2000. J. Biol. Chem. 275, 36741.
Product Information
ATP CompetitiveY
FormWhite solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₃₆H₇₅N₂₅O₆
Chemical formulaC₃₆H₇₅N₂₅O₆
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary Targetfurin
Primary Target K<sub>i</sub>106 nM against Furin
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-(D)Arg-Arg-Arg-Arg-Arg-Arg-NH₂
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
344931-1MG 04055977194395