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344216 Formyl Peptide Receptor-Like 1 Agonist, WKYMVm - Calbiochem

The Formyl Peptide Receptor-Like 1 Agonist, WKYMVm controls the biological activity of Formyl Peptide Receptor-Like 1. This small molecule/inhibitor is primarily used for Activators/Inducers applicati

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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: H₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm

344216
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Overview

Products

Catalogue NumberPackaging Qty/Pack
344216-5MG Plastic ampoule 5 mg
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Description
OverviewA potent chemoattractant that enhances leukocyte activity via activation of Formyl Peptide Receptor-Like 1 (FPRL1). Shown to activate phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells (EC50 = 510 pM). Also shown to stimulate inositol phosphate formation in U937 and HL60 cells, but has no effect on a variety of other cell lines (e.g. NIH3T3, PC12, Daudi, Sp2, Jurkat, H9, Molt-4, SupT-1, K562, and RBL-2H3). Stimulates phagocyte chemotaxis and [Ca2+] flux, and is more effective than fMLP (Cat. No. 05-22-2500) in generating superoxide in human neutrophils. Radioiodinatable at the tyrosine residue.
Catalogue Number344216
Brand Family Calbiochem®
SynonymsH₂N-WKYMV-D-M-CONH₂, FPRL1 Agonist, WKYMVm
References
ReferencesBae, Y.S., et al. 2004. J. Immunol. 173, 607.
Bae, Y.S., et al. 2003. Mol. Pharmacol. 64, 841.
Le, Y., et al. 1999. J. Immunol. 163, 6777.
Seo, J.K., et al. 1997. J. Immunol. 158, 1895.
Baek, S.H., et al. 1996. J. Biol. Chem. 271, 8170.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₄₁H₆₁N₉O₇S₂
Chemical formulaC₄₁H₆₁N₉O₇S₂
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Biological Information
Primary TargetFormyl Peptide Receptor-Like 1
Primary Target IC<sub>50</sub>EC50 = 510 pM in activating phospholipase C-mediated inositol phosphate formation in human U266 myeloma cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Trp-Lys-Tyr-Met-Val-D-Met-CONH₂
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
344216-5MG 04055977215328