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324761 Elastase Inhibitor V - Calbiochem

Elastase Inhibitor V - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one

324761
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
324761-25MG Glass bottle 25 mg
Description
OverviewA benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine. Shown to inhibit elastase secretion (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.).
Catalogue Number324761
Brand Family Calbiochem®
Synonyms2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
References
ReferencesHsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.
Product Information
FormOff-white solid
Hill FormulaC₁₄H₇BrClNO₂
Chemical formulaC₁₄H₇BrClNO₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetElastase
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
324761-25MG 04055977216103

Documentation

Elastase Inhibitor V - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Elastase Inhibitor V - Calbiochem Certificates of Analysis

TitleLot Number
324761

References

Reference overview
Hsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-April-2013 JSW
Synonyms2-(2-Bromophenyl)-5-chloro-3,1-benzoxazin-4-one
DescriptionA benzoxazinone compound that acts as a potent inhibitor of human leukocyte elastase (IC50 = 29.5 nM), likely by covalently modifying active site serine via a Michael addition-elimination reaction. Shown to inhibit medium elastase activity (IC50 = 80.8 nM), but not O2•- generation, in fLMP (Cat. No. 05-22-2500)-stimulated primary human neutrophil cultures. Reported to reduce neutrophil infiltration in lung after hemorrhagic shock in rats in vivo (1 mg/kg, i.v.) as assessed by increase in lung wet/dry ratio (0.75- vs. 1.23-fold increase, respectively, with or without treatment) and MPO activity (1.08- vs. 3.72-fold increase, respectively, with or without treatment).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₇BrClNO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml). Use only fresh DMSO.
Storage Protect from moisture
Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesHsieh, P.W., et al. 2010. Eur. J. Med. Chem. 45, 3111.