533982 Sigma-AldrichDock5 Inhibitor, C21 - CAS 54129-15-6 - Calbiochem
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 54129-15-6 | C₁₂H₉Cl₂NO₂S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 5339820001 | Glass bottle | 50 mg |
| Description | |
|---|---|
| Overview | A cell-permeable, bioavailable, non-toxic benzenesulfonamide compound that directly blocks Dock5-mediated Rac activation (kcat/KM = 7.9 x 104 & 9.5 x 104 M-1s-1 for Rac1 & Rac2 by Dock5-DHR2, respectively) with selectivity over RhoA and Cdc42. At higher concentrations, affects Dock1 and Dock2 guanine nucleotide exchange factor activity. Shown to reversibly perturb podosome organization and inhibit osteoclastic bone degradation in a dose-dependent manner. Efficiently prevents both arthritis and metastasis-induced bone loss while preserving bone formation in several osteolytic disease mouse model (25 mg/kg, i.p. or i.v., 5 days a week for 4 weeks). Unlike alendronate (Cat. No. 126855), C21 does not impair bone formation. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water. |
| Catalogue Number | 533982 |
| Brand Family | Calbiochem® |
| Synonyms | N-(3,5-Dichlorophenyl)benzenesulfonamide |
| References | |
|---|---|
| References | Vives, V., et al. 2015. Nat. Commun. 6, 6218. Vives, V., et al. 2011. J. Bone Miner. Res. 26, 1099. |
| Product Information | |
|---|---|
| CAS number | 54129-15-6 |
| Form | Grey powder |
| Hill Formula | C₁₂H₉Cl₂NO₂S |
| Chemical formula | C₁₂H₉Cl₂NO₂S |
| Reversible | Y |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Dock5 |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5339820001 | 04055977281729 |