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219461 Cathepsin K, His•Tag®, Human, Recombinant, E. coli

219461
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Overview

Products

Catalogue NumberPackaging Qty/Pack
219461-25UG Plastic ampoule 25 μg
Description
OverviewCathepsin K is a member of the papain superfamily of cysteine proteinases and plays an important role in osteoclast-mediated bone resorption and collagen degradation. It is primarily expressed by osteoclasts and recent studies also suggest its expression in fibroblasts. Irregularities in cathepsin K activity, either too high or too low, contribute to osteopenic disorders such as osteoporosis and pycnodysostosis. This recombinant enzyme contains a C-terminal His•Tag® sequence.
Note: 1 mU = 1 milliunit.
Catalogue Number219461
Brand Family Calbiochem®
References
ReferencesDelaisse, J.M., et al. 2003. Microsc. Res. Tech. 61, 504.
Dodds, R.A. 2003. Cell Biochem. Funct. 21, 231.
Everts, V., et al. 2003. Calcif. Tissue Int. 73, 380.
Hou, W.S., et al. 2003. Biol. Chem. 384, 891.
Product Information
CAS number94716-09-3
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 0.4 µmol Z-FR-AMC per min at 37°C, pH 5.5.
EC number3.4.22.38
FormLiquid
FormulationIn 50 mM NaOAC, pH 5.5. The activation was stopped by addition of 10 mM MMTS, which can be removed under reducing conditions.
Quality LevelMQ100
Biological Information
Purity≥95% by SDS-PAGE
Specific Activity≥900 mU/mg protein
Concentration Label Please refer to vial label for lot-specific concentration
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Global Trade Item Number
Catalogue Number GTIN
219461-25UG 04055977218442