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400010 Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem

The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: IL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049

Primary Target: caspase-1, human recombinant
400010
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
143313-51-3C₂₃H₃₂N₄O₈

Products

Catalogue NumberPackaging Qty/Pack
400010-1MG Plastic ampoule 1 mg
400010-5MG Plastic ampoule 5 mg
Description
OverviewA potent, specific, and reversible inhibitor of caspase-1 (Ki = 200 pM for human recombinant caspase-1), caspase-4, and caspase-5. Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
Catalogue Number400010
Brand Family Calbiochem®
SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature 375, 81.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Wilson, K.P., et al. 1994. Nature 370, 270.
Thornberry, N.A., et al. 1992. Nature 356, 768.
Product Information
CAS number143313-51-3
ATP CompetitiveN
FormWhite powder
Hill FormulaC₂₃H₃₂N₄O₈
Chemical formulaC₂₃H₃₂N₄O₈
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1, human recombinant
Primary Target K<sub>i</sub>200 pM for human recombinant caspase-1
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
400010-1MG 04055977212600
400010-5MG 04055977212617

Documentation

Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem Certificates of Analysis

TitleLot Number
400010

References

Reference overview
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature 375, 81.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Wilson, K.P., et al. 1994. Nature 370, 270.
Thornberry, N.A., et al. 1992. Nature 356, 768.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-July-2014 JSW
SynonymsIL-1β Converting Enzyme (ICE) Inhibitor I, Ac-YVAD-CHO, L-709049
DescriptionInterleukin-1β converting enzyme (ICE) is a cysteine protease that cleaves the IL-1β precursor to mature IL-1β. ICE inhibitor I is a potent, specific, and reversible inhibitor of ICE (Ki = 200 pM for human recombinant ICE). Strongly inhibits anti-APO-1 induced apoptosis in L929-APO-1 cells.
FormWhite powder
CAS number143313-51-3
Chemical formulaC₂₃H₃₂N₄O₈
Peptide SequenceAc-Tyr-Val-Ala-Asp-CHO
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Los, M., et al. 1995. Nature 375, 81.
Walker, N.P.C., et al. 1994. Cell 78, 343.
Wilson, K.P., et al. 1994. Nature 370, 270.
Thornberry, N.A., et al. 1992. Nature 356, 768.