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208743 Calpain Inhibitor XI - CAS 145731-49-3 - Calbiochem

The Calpain Inhibitor XI, also referenced under CAS 145731-49-3, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-L-Abu-CONH(CH₂)₃-morpholine

Primary Target: calpain 1, calpain 2
208743
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Overview

Key Spec Table

CAS #Empirical Formula
145731-49-3C₂₆H₄₀N₄O₆

Products

Catalogue NumberPackaging Qty/Pack
208743-5MG Plastic ampoule 5 mg
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Description
OverviewA cell-permeable dipeptidyl α-ketoamide that acts as a potent, highly selective, reversible, and active site inhibitor of calpain-1 and -2 (Ki = 140 nM and 41 nM, respectively). Weakly inhibits cathepsin B (Ki = 6.9 µM). Reported to have a neuroprotective role in the central nervous system following focal ischemia. Also protects against virus-induced apoptotic myocardial injury in mice.
Catalogue Number208743
Brand Family Calbiochem®
SynonymsZ-L-Abu-CONH(CH₂)₃-morpholine
References
ReferencesBlomgren, K., et al. 2001. J. Biol. Chem. 276, 10191.
DeBiasi, R.L., et al. 2001. J. Virol. 75, 351.
Saatman, K.E., et al. 2000. J. Cereb. Blood Flow Metab. 20, 66.
Stelmasiak, Z., et al. 2000. Med. Sci. Monit. 6, 426.
Blomgren, K., et al. 1999. J. Biol. Chem. 274, 14046.
James, T., et al. 1998. J. Neurosci. Res. 51, 218.
Li, Z., et al. 1996. J. Med. Chem. 39, 4089.
Saatman, K.E, et al. 1996. Proc. Natl. Acad. Sci. USA 93, 3428.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Bartus, R.T., et al. 1994. Stroke 25, 2265.
Product Information
CAS number145731-49-3
ATP CompetitiveN
FormWhite to off-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₂₆H₄₀N₄O₆
Chemical formulaC₂₆H₄₀N₄O₆
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target K<sub>i</sub>140 nM and 41 nM, against calpain-1 and -2, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Abu-CONH(CH₂)₃-morpholine (Abu = α-aminobutyric acid)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
208743-5MG 04055977202809