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203734 Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem

Brevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pumiliotoxin, Dihydrobrevetoxin B

Primary Target: Voltage-dependent Na+ channel activator
203734
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
85079-48-7C₅₀H₇₂O₁₄

Products

Catalogue NumberPackaging Qty/Pack
203734-100UG Alu drum 100 μg
Description
OverviewLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
Catalogue Number203734
Brand Family Calbiochem®
SynonymsPumiliotoxin, Dihydrobrevetoxin B
References
ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
Product Information
CAS number85079-48-7
ATP CompetitiveN
FormSolid
Hill FormulaC₅₀H₇₂O₁₄
Chemical formulaC₅₀H₇₂O₁₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationBrevetoxin PbTx-3, Ptychodiscus brevis, CAS 85079-48-7, is a lipid-soluble polyether marine toxin that acts as a voltage-dependent Na+ channel activator. Causes contractile paralysis in animal models.
Biological Information
Primary TargetVoltage-dependent Na+ channel activator
Purity>95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSXW5885000
Safety Information
R PhraseR: 26/27/28

Very toxic by inhalation, in contact with skin and if swallowed.
S PhraseS: 22-36/37/39-45

Do not breathe dust.
Wear suitable protective clothing, gloves and eye/face protection.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Highly Toxic
Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
End use certificateY
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203734-100UG 04055977203868

Documentation

Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Brevetoxin PbTx-3, Ptychodiscus brevis - CAS 85079-48-7 - Calbiochem Certificates of Analysis

TitleLot Number
203734

References

Reference overview
Baden, D.G., et al. 1994. Nat. Toxins 2, 212.
Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-September-2010 JSW
SynonymsPumiliotoxin, Dihydrobrevetoxin B
DescriptionLipid-soluble polyether marine toxin produced by the red tide dinoflagellate, Ptychodiscus brevis, found along the Gulf Coast of Florida. Voltage-dependent Na+ channel activator that causes contractile paralysis in animal models by binding to a unique site on these channels. The excitatory action of brevetoxins on nerve and muscle membranes is responsible for a wide spectrum of the toxic effects, including massive transmitter release from nerve endings, muscle fasciculations, and ventricular fibrillation. The toxin does not bind to either tetrodotoxin or aconitine/veratridine sites.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
CAS number85079-48-7
RTECSXW5885000
Chemical formulaC₅₀H₇₂O₁₄
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (30 mg/ml), Methanol (30 mg/ml), Acetonitrile(30 mg/ml), Chloroform (30 mg/ml), Ethanol (10 mg/ml). Only sparingly soluble in H₂O
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot, purge with inert gas and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Store stock solutions in glass vials; brevetoxin will stick to plastic. Use teflon or silicon pipette tips.
Toxicity Highly Toxic
ReferencesBaden, D.G., et al. 1994. Nat. Toxins 2, 212.
Rein, K., et al. 1994. J. Org. Chem. 59, 2107.
Edwards, R.A., et al. 1992. Mol. Brain Res. 14, 64.
Trainer, V.L. 1991. Mol. Pharmacol. 40, 988.
Tsai, M.C., and Chen, M.L. 1991. Br. J. Pharmacol. 103, 1126.
Trainer, V.L., et al. 1990. ACS Symposium Series 418, 166.
Baden, D.G., et al. 1988. Toxicon 26, 97.
Poli, M.A., et al. 1986. Mol. Pharmacol. 30, 129.
Shimizu, Y., et al. 1986. J. Am. Chem. Soc. 108, 514.
Baden, D.G., et al. 1982. Toxicon 19, 455.
Catterfall, W.A., and Risk, M. 1981. Mol. Pharmacol. 19, 345.