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203297 Bisindolylmaleimide IV - CAS 119139-23-0 - Calbiochem

A potent, cell permeable, and selective inhibitor of protein kinase C (IC₅₀ = 87 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Arcyriarubin A, 2,3-bis(1H-Indol-3-yl)maleimide, Ro 31-6233

Primary Target: PKC
203297
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
119139-23-0C₂₀H₁₃N₃O₂

Products

Catalogue NumberPackaging Qty/Pack
203297-1MG Plastic ampoule 1 mg
Description
OverviewA potent, cell permeable, and selective inhibitor of protein kinase C (IC50 = 87 nM). Inhibits protein kinase A at much higher concentrations (IC50 = 2.7 µM).
Catalogue Number203297
Brand Family Calbiochem®
SynonymsArcyriarubin A, 2,3-bis(1H-Indol-3-yl)maleimide, Ro 31-6233
References
ReferencesFabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Product Information
CAS number119139-23-0
ATP CompetitiveN
FormDark orange powder or solid
Hill FormulaC₂₀H₁₃N₃O₂
Chemical formulaC₂₀H₁₃N₃O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>87 nM against protein kinase C
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
203297-1MG 04055977221190

Documentation

Bisindolylmaleimide IV - CAS 119139-23-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bisindolylmaleimide IV - CAS 119139-23-0 - Calbiochem Certificates of Analysis

TitleLot Number
203297

References

Reference overview
Fabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-February-2019 JSW
SynonymsArcyriarubin A, 2,3-bis(1H-Indol-3-yl)maleimide, Ro 31-6233
DescriptionA cell-permeable potent and selective inhibitor of protein kinase C (IC50 = 87 nM) and protein kinase A (IC50 = 2.7 µM).
FormDark orange powder or solid
CAS number119139-23-0
Chemical formulaC₂₀H₁₃N₃O₂
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityMethanol (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesFabre, S., et al. 1993. Bioorg. Med. Chem. 1, 193.
Davis, P.D., et al. 1992. J. Med. Chem. 35, 177.
Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.