Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

MAB375-C Anti-Tau Antibody, clone Tau-2 (Ascites Free)

Anti-Tau Antibody, clone Tau-2 (Ascites Free) is an antibody against Tau for use in Immunohistochemistry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: MAPT, TAU UniProt Number: P29172
MAB375-C
100 μg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RIHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB375-C
ReplacesMAB375
DescriptionAnti-Tau Antibody, clone Tau-2 (Ascites Free)
Alternate Names
  • Microtubule-associated protein tau
  • Neurofibrillary tangle protein
  • Paired helical filament-tau
  • PHF-tau
  • Tau
Background InformationMicrotubule-associated protein tau (UniProt P29172; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU) gene (Gene ID 281296) in bovine species. Extracellular plaque deposits composed of amyloid-β and intracellular neurofibrillary tangles (NFTs) composed of truncated and hyperphosphorylated tau are two neuropathological hallmarks of Alzheimer's disease (AD). Tau pathology (tauopathy) can cause toxicity when the brain is devoid of amyloid plaques, and tangle pathology correlates better with clinical dementia than amyloid pathology. Abnormal processing of tau by hyperphosphorylation and proteolytic truncation contribute to the toxicity of tau. Tau is known to be cleaved by various proteases, including caspases, calpains, cathepsins, thrombin, and puromycin-sensitive aminopeptidase, as well as the lysosomal cysteine proteinase asparagine endopeptidase (AEP). MAPK, GSK-3, and Cdk-5 are three known kinases that target various tau phosphorylation sites. Tau also undergoes other types of posttranslational modifications, including glycosylation, ubiquitination, glycation, polyamination, nitration, and lysine methylation, which are believed to be important for its non-pathological functions, including polymerization and stabilization of microtubules.
Product Information
FormatPurified
PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-Tau Antibody, clone Tau-2 (Ascites Free) is an antibody against Tau for use in Immunohistochemistry.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry Analysis: A 1:5,000 dilution from a representative lot detected Tau in rat kidney tissue.
Biological Information
ImmunogenBovine Tau.
CloneTau-2
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityTau from bovine, feline and abnormal human tau in Alzheimer's disease.
IsotypeIgG1κ
Species Reactivity
  • Human
  • Rat
Species Reactivity NoteHuman, Rat. Predicted to react with Bovine, Feline based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • MAPT
  • TAU
Purification MethodProtein G Purified
UniProt Number
Molecular Weight46 kDa calculated
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in Alzheimer's diseased human cerebral cortex tissue.

Immunohistochemistry Analysis: A 1:5,000 dilution of this antibody detected Tau-positive plaques in Alzheimer's diseased human cerebral cortex tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Global Trade Item Number
Catalogue Number GTIN
MAB375-C 04055977294873