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MABF1458 Sigma-AldrichAnti-TCR beta chain (mouse), violetFluor™ 450, clone H57-597 Antibody

This armenian hamster monoclonal Anti-TCR beta chain Antibody (mouse), violetFluor™ 450, clone H57-597, Cat. No. MABF1458 is validated for use in Flow Cytometry, for the detection of TCR beta chain.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: Ptcra UniProt Number: P0C6B2

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Overview

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	FC	AHm	violetFluor™ 450	Monoclonal Antibody

Description
Catalogue Number	MABF1458
Description	Anti-TCR beta chain (mouse), violetFluor™ 450, clone H57-597 Antibody
Alternate Names	Pre T-cell antigen receptor alpha (pT-alpha or pTa) gp33 pT-alpha-TCR TCR beta chain
Background Information	The H57-597 antibody is specific for the beta chain of the mouse T cell Receptor (TCR). This cell surface protein combines with a second protein chain (alpha chain) to form the alpha-beta TCR that is expressed by NK1.1+ thymocytes, NKT cells, and the majority of peripheral T cells. A small number of T cells may express an alternative heteromer of gamma/delta protein chains, known as the g/d TCR. These receptors participate in a complex with CD3, and with the co-receptors CD4 or CD8, to recognize and respond to antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death.The H57-597 antibody is used as a phenotypic marker for T cells expressing the alpha-beta TCR. It is also widely used to cross-link surface TCR and thereby mimic TCR-mediated cell activation or induction of apoptosis. The antibody does not cross-react with cells expressing the g/d TCR.

Product Information
Format	violetFluor™ 450
Presentation	Purified Armenian Hamster monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality Level	MQ100

Applications
Application	This armenian hamster monoclonal Anti-TCR beta chain Antibody (mouse), violetFluor™ 450, clone H57-597, Cat. No. MABF1458 is validated for use in Flow Cytometry, for the detection of TCR beta chain.
Key Applications	Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	H57-597
Concentration	Please refer to lot specific datasheet.
Host	Armenian Hamster
Isotype	IgG
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	Ptcra
Purification Method	Purified by size-exclusion chromatography
UniProt Number	P0C6B2

Product Usage Statements
Quality Assurance	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.25 μg from a representative lot detected TCR beta chain in one million C57Bl/6 splenocytes.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	25 μg

Global Trade Item Number
Catalogue Number	GTIN
MABF1458	04055977291780

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