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MABS1882 Anti-TAOK3 Antibody, clone 1H9.1

Detect TAOK3 using this mouse monoclonal Anti-TAOK3 Antibody, clone 1H9.1, Cat. No. MABS1882. It has been tested in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-TAOK3 Antibody, clone 1H9.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Gene Symbol: TAOK3, DPK, JIK, KDS, MAP3K18 UniProt Number: Q9H2K8
MABS1882
100 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWB, IH(P)MPurifiedMonoclonal Antibody
Description
Catalogue NumberMABS1882
DescriptionAnti-TAOK3 Antibody, clone 1H9.1
Alternate Names
  • Serine/threonine-protein kinase TAO3
  • EC:2.7.11.1
  • Cutaneous T-cell lymphoma-associated antigen HD-CL-09
  • CTCL-associated antigen HD-CL-09
  • Dendritic cell-derived protein kinase
  • JNK/SAPK-inhibitory kinase
  • Jun kinase-inhibitory kinase
  • JIK
  • Kinase from chicken homolog A
  • hKFC-A
  • Thousand and one amino acid protein 3
Background InformationSerine/threonine-protein kinase TAO3 (UniProt: Q9H2K8; also known as EC:2.7.11.1, Cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein kinase, JNK/SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, JIK, Kinase from chicken homolog A, hKFC-A, Thousand and one amino acid protein 3) is encoded by the TAOK3 (also known as DPK, JIK, KDS, MAP3K18) gene (Gene ID: 51347) in human. TAO kinase 3 is a member of the STE20 subfamily of the STE Ser/Thr protein kinases. It is a serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. In response to DNA damage at the G2/M phase, it is phosphorylated at Ser324 by ATM and acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. It is shown to inhibit basal activity of MAPK8/JNK cascade and also diminishes its activation in response epidermal growth factor. TAO kinase 3 is highly expressed in peripheral blood leukocytes, thymus, spleen, kidney, skeletal muscle, heart, and liver.
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect TAOK3 using this mouse monoclonal Anti-TAOK3 Antibody, clone 1H9.1, Cat. No. MABS1882. It has been tested in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TAOK3 in human testis, human small intestine, and human pancreas.

Western Blotting Analysis: 0.5 µg/mL from a representative lot detected TAOK3 in 10 µg of Raw264.7 cell lysate.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 16 amino acids from the C-terminus end of human Serine/threonine-protein kinase TAO3 (TAOK3).
Clone1H9.1
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone 1H9.1 specifically detects Serine/threonine-protein kinase TAO3 (TAOK3) in K562 cells. It targets an epitope of 16 amino acids in the C-terminal region.
IsotypeIgG2aκ
Species Reactivity
  • Human
  • Mouse
Species Reactivity NoteHuman, Mouse.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TAOK3
  • DPK
  • JIK
  • KDS
  • MAP3K18
Purification MethodProtein G purified
UniProt Number
Molecular Weight~120 kDa observed, 105.41 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in K562 cells.

Western Blotting Analysis: 0.5 µg/mL of this antibody detected TAOK3 in 10 µg of K562 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MABS1882 04054839179037