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MAB1564 Anti-Serotonin Transporter Antibody, clone 17-7A4

MAB1564
100 µg  
Purchase on Sigma-Aldrich

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Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
RIHCMPurifiedMonoclonal Antibody
Description
Catalogue NumberMAB1564
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Serotonin Transporter Antibody, clone 17-7A4
References
Product Information
FormatPurified
HS Code3002 15 90
Control
  • Brain tissue
PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Quality LevelMQ100
Applications
ApplicationDetect Serotonin Transporter using this Anti-Serotonin Transporter Antibody, clone 17-7A4 validated for use in IH.
Key Applications
  • Immunohistochemistry
Application NotesImmunohistochemistry: 0.5-1.0 μg/mL on paraformaldehyde fixed brain and adrenal tissue. Has not been tested on paraffin embedded tissue. Not recommended for use in Western blotting. Optimal working dilutions must be determined by end user.
Biological Information
ImmunogenRat serotonin transporter, N-terminus/GST fusion protein (aa 1-85).
Clone17-7A4
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityRecognizes Serotonin Transporter.
IsotypeIgG1
Species Reactivity
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene SummaryThis gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma.
Gene Symbol
  • 5HTT
  • SC6A4
  • SLC6A4
  • HTT
  • SERT
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P31645 # Terminates the action of serotonin by its high affinity sodium-dependent reuptake into presynaptic terminals.
SIZE: 630 amino acids; 70325 Da
SUBUNIT: Interacts with TGFB1I1.
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P31645 ## Belongs to the sodium:neurotransmitter symporter (SNF) family.
MISCELLANEOUS: This protein is the target of psychomotor stimulants such as amphetamines or cocaine.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB1564 04053252466953

Documentation

Anti-Serotonin Transporter Antibody, clone 17-7A4 SDS

Title

Safety Data Sheet (SDS) 

Anti-Serotonin Transporter Antibody, clone 17-7A4 Certificates of Analysis

TitleLot Number
MOUSE ANTI-SEROTONIN TRANSPORTER 2840465
MOUSE ANTI-SEROTONIN TRANSPORTER - 2923265 2923265
MOUSE ANTI-SEROTONIN TRANSPORTER - 4147703 4147703
MOUSE ANTI-SEROTONIN TRANSPORTER -2705080 2705080
MOUSE ANTI-SEROTONIN TRANSPORTER -2792490 2792490
MOUSE ANTI-SEROTONIN TRANSPORTER MONOCLONAL ANTIBODY 2880943
MOUSE ANTI-SEROTONIN TRANSPORTER MONOCLONAL ANTIBODY 3035176
MOUSE ANTI-SEROTONIN TRANSPORTER MONOCLONAL ANTIBODY 3117318
MOUSE ANTI-SEROTONIN TRANSPORTER MONOCLONAL ANTIBODY - 2384709 2384709
MOUSE ANTI-SEROTONIN TRANSPORTER MONOCLONAL ANTIBODY -2506370 2506370

References

Reference overviewPub Med ID
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.
Lopez, JP; Lim, R; Cruceanu, C; Crapper, L; Fasano, C; Labonte, B; Maussion, G; Yang, JP; Yerko, V; Vigneault, E; El Mestikawy, S; Mechawar, N; Pavlidis, P; Turecki, G
Nature medicine  20  764-8  2014

Show Abstract
24908571 24908571
Amphetamine-induced rotation and L-DOPA-induced dyskinesia in the rat 6-OHDA model: a correlation study.
Elisabetta Tronci,Eunju Shin,Anders Björklund,Manolo Carta,Anders Björklund
Neuroscience research  73  2012

Show Abstract
22450171 22450171
Serotonergic and dopaminergic mechanisms in graft-induced dyskinesia in a rat model of Parkinson's disease.
Eunju Shin,Joanna Garcia,Christian Winkler,Anders Björklund,Manolo Carta
Neurobiology of disease  47  2012

Show Abstract
22579773 22579773
Coexpression of serotonin and nitric oxide in the raphe complex: cortical versus subcortical circuit.
Yuefeng Lu,Kimberly L Simpson,Kristin J Weaver,Rick C S Lin
Anatomical record (Hoboken, N.J. : 2007)  293  2010

Show Abstract
20734426 20734426
Postnatal changes in tryptophan hydroxylase and serotonin transporter immunoreactivity in multiple brainstem nuclei of the rat: Implications for a sensitive period.
Liu, Qiuli and Wong-Riley, Margaret T T
J. Comp. Neurol., 518: 1082-97 (2010)  2010

Show Abstract
20127812 20127812
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
Carlsson, T; Carta, M; Muñoz, A; Mattsson, B; Winkler, C; Kirik, D; Björklund, A
Brain : a journal of neurology  132  319-35  2009

Show Abstract
19039008 19039008
Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease.
Carlsson, T; Carta, M; Winkler, C; Björklund, A; Kirik, D
The Journal of neuroscience : the official journal of the Society for Neuroscience  27  8011-22  2007

Show Abstract
17652591 17652591
Insertion mutation at the C-terminus of the serotonin transporter disrupts brain serotonin function and emotion-related behaviors in mice.
S Zhao, J Edwards, J Carroll, L Wiedholz, R A Millstein, C Jaing, D L Murphy, T H Lanthorn, A Holmes
Neuroscience  140  321-34  2006

Show Abstract
16542782 16542782
Modulation of the trafficking of the human serotonin transporter by human alpha-synuclein.
Christophe Wersinger, Milan Rusnak, Anita Sidhu
The European journal of neuroscience  24  55-64  2006

Show Abstract
16882008 16882008
Normal development of serotonergic neurons in mice lacking S100B.
Hiroshi Nishiyama, Masaaki Takemura, Takehiro Takeda, Shigeyoshi Itohara
Neuroscience letters  321  49-52  2002

Show Abstract
11872254 11872254

Data Sheet

Title
MOUSE ANTI-SEROTONIN TRANSPORTER