118490 Sigma-AldrichATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem
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MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor
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Overview
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Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 118490-10MG | Glass bottle | 10 mg |
| Description | |
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| Overview | A cell-permeable dipeptide that reversibly blocks the homodimerization of aminoimidazole carboxamide ribonucleotide transformylase/inosine nomophosphate cyclohydrolase (ATIC) and inhibits its activity (Ki = 691 nM, Kd = 240 nM). AITC is a bifunctional enzyme that catalyzes the last two steps of de novo purine biosynthesis. Increases the intracellular levels of AICAR leading to the activation of AMP-activated protein kinase (AMPK). Shown to reduce cell viability in a dose-dependent manner. Exhibits a longer half-life and sustained AMPK activation (~ 24 hours) compared to AICA-riboside (Cat. No. 123040). |
| Catalogue Number | 118490 |
| Brand Family | Calbiochem® |
| Synonyms | AMPK Signaling Activator XI, Ac-Arg-Ph(4-NO2)-NEt2, ATIC Inhibitor, AICAR Tfase Inhibitor, AICAR transformylase Inhibitor, AICAR Tranformylase/Inosine Monophosphate Cyclohydrolase Dimerization Inhibitor |
| References | |
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| References | Spurr, I.B., et al. 2012. ChemBioChem 13, 1628. |
| Product Information | |
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| CAS number | 1402453-15-9 |
| Form | White solid |
| Hill Formula | C₂₁H₃₃N₇O₅ |
| Chemical formula | C₂₁H₃₃N₇O₅ |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | ATIC |
| Primary Target K<sub>i</sub> | 691 nM (Kd |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Peptide Sequence | Ac-Arg-Ph(4-NO2)-NEt2 |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 118490-10MG | 04055977224023 |
Documentation
ATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem SDS
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ATIC Dimerization Inhibitor - CAS 1402453-15-9 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 118490 |
References
| Reference overview |
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| Spurr, I.B., et al. 2012. ChemBioChem 13, 1628. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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