Chromolith® HPLC columns

Features and Benefits at a Glance

Merck's Chromolith® columns for high-performance liquid chromatography (HPLC) not only offer high-throughput analysis at low back pressure, but also several additional advantages.

1. Cost Savings

   • Cost and time savings due to increased sample throughput compensate for the expense of method revalidation within just one month

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2. Analysis Speed

   • Separations two times faster at half the back pressure compared to 5 μm columns
   • Higher sample throughput – separations up to nine times faster if required
   • Fast column re-equilibration between analyses

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3. System Security

   • Improved robustness, reliability and versatility
   • Significantly longer column lifetime
   • Reduced maintenance on HPLC pump and injector seals
   • Reduced need for sample preparation as columns are very resistant to blocking (even with biological samples)
   • Suitable for use with standard HPLC instruments
   • Chromolith® columns cladded in PEEK are very easy to use and handle

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4. Separation Efficiency

   • Column length no longer pressure limited
   • Very high separation efficiency by column coupling
   • Variety of column lengths available for samples of different complexities

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5. Flow Programming

   • Chromolith® columns respond quickly to changes in flow rate

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6. Flow Range

   • Wide optimal flow ranges

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