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677181 Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem

Indole alkaloid that binds to tubulin, inhibiting formation of microtubules.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Tubulin
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677181
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
2068-78-2C₄₆H₅₆N₄O₁₀ · H₂SO₄

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677181-10MG
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      		 Plastic ampoule 10 mg
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      Description
      OverviewIndole alkaloid that binds to tubulin, inhibiting formation of microtubules. Depolymerizes microtubules. Induces increase in micronuclei and delays cell cycle progression. Anti-neoplastic agent. Induces apoptosis in human lymphoma cells by disrupting microtubules.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number677181
      Brand Family Calbiochem®
      References
      ReferencesChan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
      Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
      Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
      Product Information
      CAS number2068-78-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
      Chemical formulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTubulin
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOH6340000
      Safety Information
      R PhraseR: 36/37/38-60-61

      Irritating to eyes, respiratory system and skin.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 22-26-36/37/39-45

      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      677181-10MG 04055977260601

      Documentation

      Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Vincristine Sulfate, Apocynaceae sp. - CAS 2068-78-2 - Calbiochem Certificates of Analysis

      TitleLot Number
      677181

      References

      Reference overview
      Chan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
      Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
      Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2017 JSW
      DescriptionIndole alkaloid that binds to tubulin, inhibiting the formulation of microtubules. Depolymerizes microtubules. Induces an increase in the micronucleus and delays cell cycle progression. Antineoplastic agent. Induces apoptosis in human lymphoma cells by distributing microtubules.
      FormWhite solid
      CAS number2068-78-2
      RTECSOH6340000
      Chemical formulaC₄₆H₅₆N₄O₁₀ · H₂SO₄
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityH₂O (20 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, refrigerate (4°C). Stock solutions are stable for up to 1 month at 4°C.
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 9986
      ReferencesChan, M.W., et al. 1998. Cancer Biochem. Biophys. 16, 347.
      Hanauske, A.R., et al. 1994. Eur. J. Cancer 30A, 1688.
      Takano, Y., et al. 1993. Pathol. Res. Pract. 189, 187.