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575310 T0901317 - CAS 293754-55-9 - Calbiochem

A cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC₅₀ of 20 nM for LXRα).

T0901317 - CAS 293754-55-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: TO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide

Primary Target: Liver X receptor (LXRα)
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
293754-55-9C₁₇H₁₂NSO₃F₉

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      Description
      OverviewA cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 of 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis and raise both the levels of serum HDL cholesterol and triglyceride in mice. Also reduces the development of atherosclerosis in LDL receptor-deficient mice and lowers plasma glucose in diabetic rodents.
      Catalogue Number575310
      Brand Family Calbiochem®
      SynonymsTO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
      References
      ReferencesTerasaka, N., et al. 2003. FEBS Lett. 536, 6.
      Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
      Field, F.J., et al. 2002. Biochem. J. 368, 855.
      Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
      DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
      Repa, J.J., et al. 2000. Science 289, 1524.
      Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.
      Product Information
      CAS number293754-55-9
      ATP CompetitiveN
      FormLight beige solid
      Hill FormulaC₁₇H₁₂NSO₃F₉
      Chemical formulaC₁₇H₁₂NSO₃F₉
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLiver X receptor (LXRα)
      Primary Target IC<sub>50</sub>EC50 = 20 nM for LXRα
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      575310-10MG 04055977189254

      Documentation

      T0901317 - CAS 293754-55-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      T0901317 - CAS 293754-55-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      575310

      References

      Reference overview
      Terasaka, N., et al. 2003. FEBS Lett. 536, 6.
      Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
      Field, F.J., et al. 2002. Biochem. J. 368, 855.
      Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
      DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
      Repa, J.J., et al. 2000. Science 289, 1524.
      Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-May-2014 JSW
      SynonymsTO-901317, N-(2,2,2-Trifluoroethyl)-N-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoromethylethyl)phenyl]sulfonamide
      DescriptionA cell-permeable, nonsterol, benzenesulfonamide compound that acts as a highly selective and potent liver X receptor agonist (EC50 = 20 nM for LXRα). Reported to induce the expression of genes associated with fatty acid biosynthesis. Raises the levels of serum HDL cholesterol and triglycerides in mice and inhibits the development of atherosclerosis in LDL receptor-deficient mice. Also shown to lower plasma glucose levels in diabetic rodents.
      FormLight beige solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number293754-55-9
      Chemical formulaC₁₇H₁₂NSO₃F₉
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (50 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesTerasaka, N., et al. 2003. FEBS Lett. 536, 6.
      Cao, G., et al. 2002. J. Biol. Chem. 278, 1131.
      Field, F.J., et al. 2002. Biochem. J. 368, 855.
      Fukumoto, H., et al. 2002. J. Biol. Chem. 277, 48508.
      DeBose-Boyd, R.A., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 1477.
      Repa, J.J., et al. 2000. Science 289, 1524.
      Schultz, J.R., et al. 2000. Genes Dev. 14, 2831.