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574776 Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem

A dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Disrupts the actin cytoskeleton
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574776
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
95927-67-6C₇₈H₁₃₂O₂₀

Pricing & Availability

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574776-10UG
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      		 Plastic ampoule 10 μg
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      Description
      OverviewA dimeric dilactone macrolide that is cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal properties.
      Catalogue Number574776
      Brand Family Calbiochem®
      References
      ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
      Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
      Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
      Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
      Product Information
      CAS number95927-67-6
      ATP CompetitiveN
      FormColorless oil
      Hill FormulaC₇₈H₁₃₂O₂₀
      Chemical formulaC₇₈H₁₃₂O₂₀
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDisrupts the actin cytoskeleton
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      574776-10UG 04055977189728

      Documentation

      Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Swinholide A, Theonella swinhoei - CAS 95927-67-6 - Calbiochem Certificates of Analysis

      TitleLot Number
      574776

      References

      Reference overview
      Saito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
      Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
      Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
      Doi, M., et al. 1991. J. Org. Chem. 56, 3629.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      DescriptionA dimeric dilactone macrolide isolated from the marine sponge Theonella swinhoei. Cytotoxic to a variety of cancer cell lines in vitro. Disrupts the actin cytoskeleton by sequestering actin dimers with a binding stoichiometry of 1:1, and rapidly severing F-actin. Also possesses antifungal activity.
      FormColorless oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number95927-67-6
      Chemical formulaC₇₈H₁₃₂O₂₀
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityEthanol or acetone
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSaito, S.Y., et al. 1998. J. Biochem. (Tokyo) 123, 571.
      Bubb, M.R., et al. 1995. J. Biol. Chem. 270, 3463.
      Kobayashi, M., et al. 1994. Chem. Pharm. Bull. 42, 19.
      Doi, M., et al. 1991. J. Org. Chem. 56, 3629.