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567375 Smac-N7 Peptide, Cell-Permeable - Calbiochem

The Smac-N7 peptide is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: AVPIAQKPRQIKIWFQNRRMKWKK

Primary Target: Promotes procaspase-3 activation
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567375
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₁₄₂H₂₃₂N₄₄O₂₉S

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567375-1MG
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      		 Plastic ampoule 1 mg
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      Description
      OverviewThe Smac-N7 peptide (Cat. No. 567370) is modified to be cell permeant by linking the lysine carboxyl terminal to the arginine of Antennapedia homeodomain 16-mer peptide via a proline linker.
      Catalogue Number567375
      Brand Family Calbiochem®
      SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
      References
      ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
      Chai, J., et al. 2000. Nature 406, 855.
      Liu, Z., et al. 2000. Nature 408, 1004.
      Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₁₄₂H₂₃₂N₄₄O₂₉S
      Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPromotes procaspase-3 activation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      567375-1MG 07790788051594

      Documentation

      Smac-N7 Peptide, Cell-Permeable - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Smac-N7 Peptide, Cell-Permeable - Calbiochem Certificates of Analysis

      TitleLot Number
      567375

      References

      Reference overview
      Srinivasula, S.M., et al. 2001. Nature 410, 112.
      Chai, J., et al. 2000. Nature 406, 855.
      Liu, Z., et al. 2000. Nature 408, 1004.
      Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.

      Brochure

      Title
      Caspases and other Apoptosis Related Tools Brochure
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-September-2008 RFH
      SynonymsAVPIAQKPRQIKIWFQNRRMKWKK
      DescriptionThe Smac-N7 peptide (Cat. No. 567370) where the lysine carboxy terminal is linked to the arginine of Antennapedia homeodomain 16-mer peptide (underlined) via a proline linker to make it cell-permeable. Smac-N7 peptide contains the N-terminal seven residues of Smac and promotes the activation of procaspase-3 (~10 µM). Also, promotes the catalytic activity of caspase-9 in the presence of XIAP.
      FormLyophilized
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₄₂H₂₃₂N₄₄O₂₉S
      Peptide SequenceH-Ala-Val-Pro-Ile-Ala-Gln-Lys-Pro-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSrinivasula, S.M., et al. 2001. Nature 410, 112.
      Chai, J., et al. 2000. Nature 406, 855.
      Liu, Z., et al. 2000. Nature 408, 1004.
      Srinivasula, S.M., et al. 2000. J. Biol. Chem. 275, 36152.