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572650 SU9516 - CAS 666837-93-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
666837-93-0C₁₃H₁₁N₃O₂

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572650-5MG
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      Description
      OverviewA cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
      Catalogue Number572650
      Brand Family Calbiochem®
      Synonyms3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
      References
      ReferencesYu, B., et al. 2002. Biochem. Pharmacol. 64, 1091.
      Lane, M.E., et al. 2001. Cancer Res. 61, 6170.
      Product Information
      CAS number666837-93-0
      ATP CompetitiveY
      FormYellow to orange solid
      Hill FormulaC₁₃H₁₁N₃O₂
      Chemical formulaC₁₃H₁₁N₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetCdk2/A
      Primary Target IC<sub>50</sub>22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      572650-5MG 04055977266313