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The following MAPmates™ should not be plexed together:
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Buffer Detection Kit for Magnetic Beads
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572650
Sigma-AldrichSU9516 - CAS 666837-93-0 - Calbiochem
A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells.
More>>A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Less<<
SU9516 - CAS 666837-93-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Description
Overview
A cell-permeable 3-substituted indolinone compound that displays anti-proliferative and proapoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks; IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). It shows no significant effect (IC50 >10 µM) on the activities of PKC, p38, PDGFRβ, or EGFR. Inhibits the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
SU9516 - CAS 666837-93-0 - Calbiochem Certificates of Analysis
Title
Lot Number
572650
References
Reference overview
Yu, B., et al. 2002. Biochem. Pharmacol.64, 1091. Lane, M.E., et al. 2001. Cancer Res.61, 6170.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A cell-permeable, 3-substituted indolinone compound that displays anti-proliferative and pro-apoptotic properties in tumor cells. Acts as a potent, selective, reversible, and ATP-competitive inhibitor of cyclin dependent kinases (Cdks) (IC50 = 22 nM for Cdk2/A; 40 nM for Cdk1/B; 200 nM for Cdk4/D1). Exhibits no significant effect on the activities of PKC, p38, PDGFRβ, or EGFR (IC50 >10 µM). Reported to inhibit the proliferation of growth factor-stimulated colon carcinoma cells by binding to Cdk2 and preventing the phosphorylation of pRb and its dissociation from E2F.
Form
Yellow to orange solid
CAS number
666837-93-0
Chemical formula
C₁₃H₁₁N₃O₂
Structure formula
Purity
≥95% by HPLC
Solubility
DMSO (10 mg/ml)
Storage
Protect from light
+2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity
Carcinogenic / Teratogenic
References
Yu, B., et al. 2002. Biochem. Pharmacol.64, 1091. Lane, M.E., et al. 2001. Cancer Res.61, 6170.