566324 Sigma-AldrichSIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem
The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 304896-28-4 | C₂₃H₁₃Cl₂N₃O₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 566324-5MG |
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Plastic ampoule | 5 mg |
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| Description | |
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| Overview | A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control. |
| Catalogue Number | 566324 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV |
| References | |
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| References | Outerio, T.F., et al. 2007. Science 317, 516. |
| Product Information | |
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| CAS number | 304896-28-4 |
| Form | Yellow solid |
| Hill Formula | C₂₃H₁₃Cl₂N₃O₂ |
| Chemical formula | C₂₃H₁₃Cl₂N₃O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 566324-5MG | 04055977191417 |
Documentation
SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem MSDS
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SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 566324 |
References
| Reference overview |
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| Outerio, T.F., et al. 2007. Science 317, 516. |
Data Sheet
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| SIRTainty™ Class III HDAC Assay |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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