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555580 Ribavirin - CAS 36791-04-5 - Calbiochem

A non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5'-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.

Ribavirin - CAS 36791-04-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole

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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      36791-04-5C₈H₁₂N₄O₅
      Description
      OverviewA non-interferon-inducing, broad spectrum antiviral nucleoside. Reported to be active against RSV, HIV, HCV, and other infectious agents. Its metabolite, ribavirin-5′-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase.
      Catalogue Number555580
      Brand Family Calbiochem®
      Synonyms1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole
      References
      ReferencesLi, W., et al. 1999. Oncol. Res. 11, 243.
      Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
      Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
      Kakumu, S., et al. 1993. Gastroenterology 105, 507.
      Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.
      Product Information
      CAS number36791-04-5
      FormWhite solid
      Hill FormulaC₈H₁₂N₄O₅
      Chemical formulaC₈H₁₂N₄O₅
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC, ≥99% by TLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSXZ4250000
      Safety Information
      R PhraseR: 61

      May cause harm to the unborn child.
      S PhraseS: 3/7/9-22-45-53

      Keep container tightly closed, in a cool well ventilated place.
      Do not breathe dust.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      555580 0

      Documentation

      Ribavirin - CAS 36791-04-5 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Ribavirin - CAS 36791-04-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      555580

      References

      Reference overview
      Li, W., et al. 1999. Oncol. Res. 11, 243.
      Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
      Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
      Kakumu, S., et al. 1993. Gastroenterology 105, 507.
      Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-May-2008 RFH
      Synonyms1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide, Virazole
      DescriptionA non-interferon-inducing, broad spectrum antiviral nucleoside that is active against RSV, HIV, HCV and other infectious agents. Inhibits the growth of human myeloma 8226 cells (IC50 = 40 µM) and ovarian carcinoma OVCAR-5 cells (IC50 = 35 µM). Its metabolite, ribavirin-5'-phosphate, inhibits inosine monophosphate (IMP) dehydrogenase. Antiviral effects of Ribavirin can be reversed by depriving infected cells of methionine or isoleucine.
      FormWhite solid
      CAS number36791-04-5
      RTECSXZ4250000
      Chemical formulaC₈H₁₂N₄O₅
      Structure formulaStructure formula
      Purity≥99% by HPLC, ≥99% by TLC
      SolubilityDMSO and H₂O (20 mg/ml)
      Storage +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Toxicity Carcinogenic / Teratogenic
      Merck USA index14, 8198
      ReferencesLi, W., et al. 1999. Oncol. Res. 11, 243.
      Honda, Y., et al. 1994. Antimicrob. Agents Chemother. 38, 653.
      Liao, H.J. and Stollar, V. 1993. Antiviral Res. 22, 285.
      Kakumu, S., et al. 1993. Gastroenterology 105, 507.
      Sidwell, R.W., et al. 1979. Pharmacol. Ther. 6, 123.