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487928 Nocodazole - CAS 31430-18-9 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
31430-18-9C₁₄H₁₁N₃O₃S

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487928-10MG
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      Description
      OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
      Catalogue Number487928
      Brand Family Calbiochem®
      SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
      References
      ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Product Information
      CAS number31430-18-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₄H₁₁N₃O₃S
      Chemical formulaC₁₄H₁₁N₃O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.
      Biological Information
      Primary TargetPromotes tubulin depolymerization
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSDD6521000
      Safety Information
      R PhraseR: 40-63

      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      487928-10MG 04055977200386