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203996 N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: NB-DNJ, HCl, N-Butyl-DNJ, HCl

Primary Target: Ceramide-specific glycosyltransferases
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      72599-27-0C₁₀H₂₁NO₄ · HCl
      Description
      OverviewA non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

      Please note that the molecular weight for this compound is batch-specific due to variable water content.
      Catalogue Number203996
      Brand Family Calbiochem®
      SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
      References
      ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
      van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
      Platt, F.M., et al. 1997. Science 276, 428.
      Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
      Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
      Product Information
      CAS number72599-27-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₂₁NO₄ · HCl
      Chemical formulaC₁₀H₂₁NO₄ · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCeramide-specific glycosyltransferases
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      203996 0

      Documentation

      N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      N-Butyldeoxynojirimycin, Hydrochloride - CAS 72599-27-0 - Calbiochem Certificates of Analysis

      TitleLot Number
      203996

      References

      Reference overview
      Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
      van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
      Platt, F.M., et al. 1997. Science 276, 428.
      Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
      Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-November-2014 JSW
      SynonymsNB-DNJ, HCl, N-Butyl-DNJ, HCl
      DescriptionA non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number72599-27-0
      Chemical formulaC₁₀H₂₁NO₄ · HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDwek, R.A., et al. 2002. Nat. Rev. Drug Discovery 1, 65.
      van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 17173.
      Platt, F.M., et al. 1997. Science 276, 428.
      Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 2235.
      Platt, F.M., et al. 1994. J. Biol. Chem. 269, 8362.