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444264 MMP Inhibitor III - CAS 927827-98-3 - Calbiochem

The MMP Inhibitor III, also referenced under CAS 927827-98-3, controls the biological activity of MMP. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: MMP-1
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444264
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
927827-98-3C₁₉H₂₉N₃O₄

Pricing & Availability

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444264-1MG
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      Description
      OverviewA homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC50 = 7.4 nM), MMP-2 (IC50 = 2.3 nM), MMP-3 (IC50 = 135 nM), MMP-7 (IC50 = 10-100 nM), and MMP-13 (IC50 = 1-10 nM).
      Catalogue Number444264
      Brand Family Calbiochem®
      References
      ReferencesCovington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol. 290, F43.
      Product Information
      CAS number927827-98-3
      ATP CompetitiveN
      FormOff-white lyophilized solid
      Hill FormulaC₁₉H₂₉N₃O₄
      Chemical formulaC₁₉H₂₉N₃O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMMP-1
      Primary Target IC<sub>50</sub>7.4 nM, 2.3 nM, 135 nM, 10-100 nM, 1-10 nM, against MMP-1, MMP-2, MMP-3, MMP-7, and MMP-13, respectively
      Purity≥90% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      444264-1MG 07790788050382

      Documentation

      MMP Inhibitor III - CAS 927827-98-3 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      MMP Inhibitor III - CAS 927827-98-3 - Calbiochem Certificates of Analysis

      TitleLot Number
      444264

      References

      Reference overview
      Covington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol. 290, F43.

      Citations

      Title
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-June-2015 JSW
      DescriptionA homophenylalanine-hydroxamic acid based broad-spectrum cell-permeable, reversible inhibitor of matrix metalloproteinases (supplied as a racemic mixture). Inhibits MMP-1 (IC50 = 7.4 nM), MMP-2 (IC50 = 2.3 nM), MMP-3 (IC50 = 135 nM), MMP-7 (IC50 = 10-100 nM), and MMP-13 (IC50 = 1-10 nM).
      FormOff-white lyophilized solid
      CAS number927827-98-3
      Chemical formulaC₁₉H₂₉N₃O₄
      Structure formulaStructure formula
      Purity≥90% by TLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months (-20°C).
      Toxicity Standard Handling
      ReferencesCovington, M.D., et al. 2006, Am. J. Physiol. Renal. Physiol. 290, F43.
      Citation
    • Haili Su, et al. (2005) Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation 112, 3157-3167.
      		•