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475880 ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem

ML-7, Hydrochloride, CAS 110448-33-4, is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl

Primary Target: Myosin light chain kinase (Mlck)
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475880
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
110448-33-4C₁₅H₁₇IN₂O₂S · HCl

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      Description
      OverviewA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
      Catalogue Number475880
      Brand Family Calbiochem®
      Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
      References
      ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
      Product Information
      CAS number110448-33-4
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₇IN₂O₂S · HCl
      Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationML-7, Hydrochloride, CAS 110448-33-4, is a cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM).
      Biological Information
      Primary TargetMyosin light chain kinase (Mlck)
      Primary Target K<sub>i</sub>300 nM against myosin light chain kinase
      Purity>98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      475880-1MG 04055977203493

      Documentation

      ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      ML-7, Hydrochloride - CAS 110448-33-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      475880

      References

      Reference overview
      Krarup, T., et al. 1998. Am. J. Physiol. 275, C239.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-January-2010 RFH
      Synonyms1-(5-Iodonaphthalene-1-sulfonyl)homopiperazine, HCl
      DescriptionA cell-permeable, potent, reversible, ATP-competitive, and selective inhibitor of myosin light chain kinase (Ki = 300 nM). Inhibits protein kinase A (Ki = 21 µM) and protein kinase C (Ki = 42 µM) at much higher concentrations.
      FormWhite solid
      CAS number110448-33-4
      Chemical formulaC₁₅H₁₇IN₂O₂S · HCl
      Structure formulaStructure formula
      Purity>98% by TLC
      SolubilityDMSO (4.5 mg/ml) or 50% ethanol (4.5 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesKrarup, T., et al. 1998. Am. J. Physiol. 275, C239.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.