504173 Sigma-AldrichMAT2A Inhibitor II, FIDAS-5 - CAS 1391934-98-7 - Calbiochem
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 1391934-98-7 | C₁₅H₁₃ClFN |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 5.04173.0001 |
|
Glass bottle | 10 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable fluorinated N,N-dialkylaminostilbene (FIDAS) analogue of FIDAS-3 (Cat. No. 681677) that competes against SAM for MAT2A binding and is >2-fold more potent than FIDAS-3 in inhibiting MAT2A-catalyzed SAM synthesis both in cell-free assays (IC50 = 2.1 µM) and in LS174T colorectal cancer (CRC) cultures (3 µM). FIDAS-5 at 3 µM is shown to completely inhibit the proliferation of LS174T for up to 7 d in vitro and effectively suppress HT29 CRC tumor expansion in mice in vivo (20 mg/kg/day p.o.). |
| Catalogue Number | 504173 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-4-(2-Chloro-6-fluorostyryl)-N-methylaniline, Methionine S-Adenosyltransferase 2A Inhibitor II, FIDAS5 |
| References | |
|---|---|
| References | Zhang, W., et al. 2013. ACS Chem. Biol. 8, 796. |
| Product Information | |
|---|---|
| CAS number | 1391934-98-7 |
| Form | Yellow semi-solid |
| Hill Formula | C₁₅H₁₃ClFN |
| Chemical formula | C₁₅H₁₃ClFN |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | MAT2A |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 5.04173.0001 | 04055977263831 |