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437627 Lipopolysaccharide, E. coli O111: B4 - Calbiochem

Lipopolysaccharide, E. coli O111: B4 stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes

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437627
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437627-5MG
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      Description
      OverviewStimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
      Catalogue Number437627
      Brand Family Calbiochem®
      References
      ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
      Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
      O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
      Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
      Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.
      Product Information
      ATP CompetitiveN
      FormLyophilized
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetInducible nitric oxide synthase
      Physicochemical Information
      Cell permeableN
      ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOJ0895400
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      437627-5MG 04055977187472

      Documentation

      Lipopolysaccharide, E. coli O111: B4 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Lipopolysaccharide, E. coli O111: B4 - Calbiochem Certificates of Analysis

      TitleLot Number
      437627

      References

      Reference overview
      Hattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
      Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
      O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
      Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
      Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-May-2008 JSW
      DescriptionEndotoxin lipopolysaccharides initiate a variety of biochemical cell activation pathways (PKC, cAMP-dependent protein kinase, arachidonate metabolism, protein myristoylation, and activation of G-proteins). These unique macromolecules have been extensively studied in order to elucidate and define relevant pathophysiological parameters of endotoxic shock, a profound life-threatening consequence of sepsis. More recently, these bacterial products have generated intense interest due to their pluropotential immunostimulatory activity as manifested by the activation of host cells (e.g. B lymphocytes, macrophages) to functional differentiation. Host cell activation by lipopolysaccharides produces a spectrum of hormone-active lymphokines and monokines, including interferons (α, β, and γ), interleukins (IL-1 and IL-6), tumor necrosis factor, platelet activating factor, and procoagulant tissue factor. Stimulates the activity of inducible nitric oxide synthase. Induces apoptosis in mouse thymus and swine lymphocytes.
      FormLyophilized
      RTECSOJ0895400
      ContaminantsProtein: ≤2.0%; nucleic acid: ≤2.5%
      SolubilityH₂O (5 mg/ml) or 0.5% triethylamine (1 mg/ml). To achieve complete solubilization, heating solution to 37°C with intermittent vortexing or sonication may be necessary.
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Harmful
      ReferencesHattori, S., et al. 1995. Biochem. Mol. Biol. Int. 35, 177.
      Mayeux, P.R., et al. 1995. Biochem. Pharmacol. 49, 115.
      Norimatsu, M., et al. 1995. Infect. Immun. 63, 1122.
      Feinstein, D.L., et al. 1993. J. Neurochem. 60, 1945.
      Zhang, Y.H., et al. 1993. Infect. Immun. 61, 5044.
      Jackson, S.K., et al. 1992. Biochim. Biophys. Acta 1135, 165.
      O'Sullivan, M.G., et al. 1992. J. Biol. Chem. 267, 14547.
      Watanabe, K., et al. 1992. J. Cell. Physiol. 150, 433.
      Morrison, D.C., and Ryan, J.L. 1987. Annu. Rev. Med. 38, 417.