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509703 LSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
1423715-09-6C₁₉H₂₀ClN₃O₅S

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      Glass bottle 10 mg
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      Description
      OverviewA cell-permeable phenethylidene-benzohydrazide compound that acts as a potent, selective, reversible, and non-competitive inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC50 = 13 nM; Ki = 31 nM). Exhibits excellent selectivity over monoamine oxidases A and B (IC50 > 300 µM), lactate dehydrogenase, glucose oxidase, hERG, CYP1A2, CYP2D6 (IC50 ≥ 10 µM), CYP2C9 (IC50 = 8.04 µM) and CYP2C19 (IC50 = 9.76 µM). Inhibits CYP3A4 only at >200-fold higher concentration. Reduces the proliferation of several cancer cell lines, including AN3 Ca, BT-20, MCF-7, T-47D, HT29, MIA PaCa-2 and SK-N-MC (IC50 = 356, 489, 637, 649, 429, 468 and 329 nM, respectively).
      Catalogue Number509703
      Brand Family Calbiochem®
      SynonymsBHC110 Inhibitor VII, Histone Lysine Demethylase Inhibitor XIV, KIAA1718 Inhibitor VII, LSD Inhibitor VII, SP-2509
      References
      ReferencesFiskus, W., et al. 2014. Leukemia 28, 2155.
      Sorna, V., et al. 2013. J. Med. Chem. 56, 9496.
      Product Information
      CAS number1423715-09-6
      FormOff-white solid
      Hill FormulaC₁₉H₂₀ClN₃O₅S
      Chemical formulaC₁₉H₂₀ClN₃O₅S
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetLSD1
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      5.09703.0001 04055977241037