Millipore Sigma Vibrant Logo

420320 KT5720 - CAS 108068-98-0 - Calbiochem

KT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.

KT5720 - CAS 108068-98-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PKA Inhibitor VII

Primary Target: PKA
View Products on Sigmaaldrich.com
420320
View Pricing & Availability

Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
108068-98-0C₃₂H₃₁N₃O₅

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
420320-100UG
Retrieving availability...
—
Limited Availability Limited Availability
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Glass bottle 100 μg
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      420320-50UG
      Retrieving availability...
      —
      Limited Availability Limited Availability
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic ampoule 50 μg
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          Description
          OverviewA potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM) that is prepared by a chemical modification of K-252a. Does not significantly affect the activities of PKC, PKG, and MLCK. Inhibits axon branching in cultured neurons. A 2 mM (50 µg/47 µl) solution of KT 5720 (Cat. No. 420323) in DMSO is also available.
          Catalogue Number420320
          Brand Family Calbiochem®
          SynonymsPKA Inhibitor VII
          References
          ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Product Information
          CAS number108068-98-0
          ATP CompetitiveY
          FormWhite solid
          Hill FormulaC₃₂H₃₁N₃O₅
          Chemical formulaC₃₂H₃₁N₃O₅
          ReversibleY
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          ApplicationKT5720, CAS 108068-98-0, is a cell-permeable, potent, specific, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Has no significant effect on PKC, PKG & MLCK.
          Biological Information
          Primary TargetPKA
          Primary Target K<sub>i</sub>56 nM for protein kinase A
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          420320-100UG 04055977211023
          420320-50UG 04055977211030

          Documentation

          KT5720 - CAS 108068-98-0 - Calbiochem MSDS

          Title

          Safety Data Sheet (SDS) 

          KT5720 - CAS 108068-98-0 - Calbiochem Certificates of Analysis

          TitleLot Number
          420320

          References

          Reference overview
          Simpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

          Citations

          Title
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision08-January-2010 RFH
          SynonymsPKA Inhibitor VII
          DescriptionPrepared by a chemical modification of K-252a. A potent, specific, cell-permeable, reversible and ATP-competitive inhibitor of protein kinase A (Ki = 56 nM). Does not significantly affect the activity of PKC, PKG, or MLCK. Inhibits axon branching in cultured neurons.
          FormWhite solid
          CAS number108068-98-0
          Chemical formulaC₃₂H₃₁N₃O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (1 mg/ml). Further dilute with aqueous buffers just prior to use.
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Toxicity Standard Handling
          ReferencesSimpson, C.S., and Morris, B.J. 1995. Neuroscience 68, 97.
          Cabell, L., and Audesirk, G. 1993. Int. J. Dev. Neurosci. 11, 357.
          Gadbois, D.M., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 8626.
          Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
          Citation
        • Mike T. Lin, et al. (2005) Ca2+-activated K+ channel-associated phosphatase and kinase activities during development. American Journal of Physiology Heart and Circulatory Physiology 289, H414-H425.
          		•