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416157 Isohelenin, Inula sp. - Calbiochem

Isohelenin, Inula sp. - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Isoalantolactone

Primary Target: NF-κB activation
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₅H₂₀O₂
      Description
      Overview

      This product has been discontinued.



      A cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, irreversible inhibitor of NF-κB activation that acts by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB, or inhibit p59fyn and Src kinase activities. Inhibits IL-8 gene expression in cultured human respiratory epithelium in vitro, and iNOS gene expression in cultured rat aortic smooth muscle cells. Offers protection against endotoxic shock in vivo.
      Catalogue Number416157
      Brand Family Calbiochem®
      SynonymsIsoalantolactone
      References
      ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
      Mazor, R.L., et al. 2000. Cytokine 12, 239.
      Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
      Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₅H₂₀O₂
      Chemical formulaC₁₅H₂₀O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNF-κB activation
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      416157 0

      Documentation

      Isohelenin, Inula sp. - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      Isohelenin, Inula sp. - Calbiochem Certificates of Analysis

      TitleLot Number
      416157

      References

      Reference overview
      Sheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
      Mazor, R.L., et al. 2000. Cytokine 12, 239.
      Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
      Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-July-2008 RFH
      SynonymsIsoalantolactone
      DescriptionA cell-permeable sesquiterpene lactone with anti-inflammatory properties. Acts as a highly specific, potent, and irreversible inhibitor of NF-κB activation by preventing IκBα degradation. Does not affect the DNA binding activity of activated NF-κB or inhibit Fyn and Src kinase activities. Also reported to inhibit IL-8 gene expression in cultured human respiratory epithelium and iNOS gene expression in cultured rat aortic smooth muscle cells. Shown to protect against endotoxic shock in rats.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₅H₂₀O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSheehan, M., et al. 2002. J. Endotoxin. Res. 8, 99.
      Mazor, R.L., et al. 2000. Cytokine 12, 239.
      Wong. H.R., and Menendez, I.Y., 1999. Biochem. Biophys. Res. Commun. 262, 375.
      Hehner, S.P., et al. 1998. J. Biol. Chem. 273, 1288.
      Bork, P.M., et al. 1997. FEBS Lett. 402, 85.