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407673 Interleukin-8, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: rhIL-8

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407673
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Recombinant, human interleukin-8 expressed in E. coli. A potent proinflammatory cytokine produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNF-α, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. A physiological initiator of chemotactic migration of leukocytes. May be involved in chronic inflammation. IL-8 acts as an angiogenic factor in human gastric carcinoma.
      Catalogue Number407673
      Brand Family Calbiochem®
      SynonymsrhIL-8
      References
      ReferencesKido, S., et al. 2001. Eur. J. Cancer 37, 1482.
      Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
      Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
      Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
      Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
      Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
      Schröeder, J., et al. 1987. J. Immunol. 139, 3474.
      Product Information
      FormLyophilized
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils
      Purity≥97% by SDS-PAGE
      Physicochemical Information
      ContaminantsEndotoxin: ≤100 EU/µg IL-8
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      407673 0

      Documentation

      Interleukin-8, Human, Recombinant, E. coli MSDS

      Title

      Safety Data Sheet (SDS) 

      Interleukin-8, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      407673

      References

      Reference overview
      Kido, S., et al. 2001. Eur. J. Cancer 37, 1482.
      Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
      Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
      Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
      Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
      Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
      Schröeder, J., et al. 1987. J. Immunol. 139, 3474.

      Citations

      Title
    • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
      		•
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision14-July-2008 RFH
      SynonymsrhIL-8
      DescriptionRecombinant, human interleukin-8 expressed in E. coli. IL-8 is produced by monocytes, fibroblasts, and keratinocytes in response to stimulation by LPS, IL-1, or TNFα, and by T lymphocytes in response to PHA stimulation. Induces adhesion of neutrophils to endothelial cells. May be involved in chronic inflammation.
      FormLyophilized
      Purity≥97% by SDS-PAGE
      ContaminantsEndotoxin: ≤100 EU/µg IL-8
      Biological activityED₅₀ = 150-300 ng/ml as measured by induction of myeloperoxidase release from human neutrophils
      SolubilityReconstitute to a concentration ≥10 µg/ml with sterile PBS containing at least 0.1% HSA or BSA.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C) for long term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 month at 4°C or up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
      Toxicity Standard Handling
      ReferencesKido, S., et al. 2001. Eur. J. Cancer 37, 1482.
      Wilson, A.J., et al. 1999. Clin. Sci. 97, 385.
      Harada, A., et al. 1994. J. Leukoc. Biol. 56, 559.
      Mazzucchelli, L., et al. 1994. Am. J. Pathol. 144, 997.
      Oppenheim, J.J., et al. 1991. Annu. Rev. Immunol. 9, 617.
      Matsushima, K., et al. 1988. J. Exp. Med. 167, 1883.
      Schröeder, J., et al. 1987. J. Immunol. 139, 3474.
      Citation
    • Felicity J. Ashcroft, et al. (2004) Control of expression of the lectin-like protein Reg-1 by gastrin: role of the Rho family GTPase RhoA and a C-rich promoter element. Biochemical Journal 381, 397-403.
      		•