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553212 InSolution™ Rapamycin in EtOH

The InSolution™ Rapamycin, also referenced under CAS 53123-88-9, controls the biological activity of mTOR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

InSolution™ Rapamycin in EtOH MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Sirolimus, mTOR Inhibitor I

553212
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₅₁H₇₉NO₁₃
      Description
      Catalogue Number553212
      Brand Family Calbiochem®
      SynonymsSirolimus, mTOR Inhibitor I
      References
      ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
      Braun, W., et al. 1995. FASEB J. 9, 63.
      Nielsen, F.C., et al. 1995. Nature 377, 358.
      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
      Kuo, J., et al. 1992. Nature 358, 70.
      Price, D.J., et al. 1992. Science 257, 973.
      Heitman, J., et al. 1991. Science 253, 905.
      Kay, J.E., et al. 1991. Immunology 72, 544.
      Schreiber, S.L. 1991. Science 251, 283.
      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
      Product Information
      FormLiquid
      FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
      Hill FormulaC₅₁H₇₉NO₁₃
      Chemical formulaC₅₁H₇₉NO₁₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 11

      Highly flammable.
      S PhraseS: 16-7

      Keep away from sources of ignition - No Smoking.
      Keep container tightly closed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      553212 0

      Documentation

      InSolution™ Rapamycin in EtOH MSDS

      Title

      Safety Data Sheet (SDS) 

      InSolution™ Rapamycin in EtOH Certificates of Analysis

      TitleLot Number
      553212

      References

      Reference overview
      Powell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
      Braun, W., et al. 1995. FASEB J. 9, 63.
      Nielsen, F.C., et al. 1995. Nature 377, 358.
      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
      Kuo, J., et al. 1992. Nature 358, 70.
      Price, D.J., et al. 1992. Science 257, 973.
      Heitman, J., et al. 1991. Science 253, 905.
      Kay, J.E., et al. 1991. Immunology 72, 544.
      Schreiber, S.L. 1991. Science 251, 283.
      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision22-September-2008 JSW
      SynonymsSirolimus, mTOR Inhibitor I
      DescriptionSelectively inhibits the phosphorylation and activation of p70 S6 kinase (IC50 = 0.05 nM). Prevents the translational activation of IGF-II. Also prevents resting T-cells from entering the cell cycle, but does not directly arrest cell cycle progression. Shown to inhibit later signaling events, such as p110Rb phosphorylation, p34cdc2 kinase activation, and cyclin A synthesis. Exhibits strong binding to FK-506 binding proteins. Also reported to induce apoptosis in a murine B-cell line, to inhibit lymphokine-induced cell proliferation at the G1 phase, and to irreversibly arrest Saccharomyces cerevisiae cells in the G1 phase.
      FormLiquid
      FormulationA 10 mM (1 mg/109 µl) solution of Rapamycin (Cat. No. 553210) in EtOH.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₅₁H₇₉NO₁₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      Merck USA index14, 8114
      ReferencesPowell, D.J., et al. 2003. Mol. cell Biol. 23, 7794.
      Braun, W., et al. 1995. FASEB J. 9, 63.
      Nielsen, F.C., et al. 1995. Nature 377, 358.
      Aagaard-Tillery, K.M. and Jelinek, D.F. 1994. Cell. Immunol. 156, 493.
      Gottschalk, A.R., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 7350.
      Morice, W.G., et al. 1993. J. Biol. Chem. 268, 3734.
      Terada, N., et al. 1993. J. Biol. Chem. 268, 12062.
      Kuo, J., et al. 1992. Nature 358, 70.
      Price, D.J., et al. 1992. Science 257, 973.
      Heitman, J., et al. 1991. Science 253, 905.
      Kay, J.E., et al. 1991. Immunology 72, 544.
      Schreiber, S.L. 1991. Science 251, 283.
      Bierer, B.E., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 9231.
      Dumont, F.J., et al. 1990. J. Immunol. 144, 251.