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371962 InSolution™ H-89, Dihydrochloride - Calbiochem

InSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III

Primary Target: PKA
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371962
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Overview

Key Spec Table

Empirical Formula
C₂₀H₂₀BrN₃O₂S

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      Description
      Catalogue Number371962
      Brand Family Calbiochem®
      SynonymsN-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl, PKA Inhibitor III
      References
      ReferencesLeemhuis, J., et al. 2002. J. Pharmacol. Exp. Ther. 300, 1000.
      Davies, S.P. et al. 2000. Biochem. J. 351, 95.
      de Rooij, J., et al. 1998. Nature. 396, 474.
      Kawasaki, H., et al. 1998. Science. 282, 2275.
      Findik, D., et al. 1995. J. Cell. Biochem. 57, 12.
      Hidaka, H., and Kobayashi, R. 1992. Annu. Rev. Pharmacol. Toxicol. 32, 377.
      Geilen, C.C., et al. 1992. FEBS Lett. 309, 381.
      Chijiwa, T., et al. 1990. J. Biol. Chem. 265, 5267.
      Combest, W.L., et al. 1988. J. Neurochem. 51, 1581.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationA 10 mM (1 mg/193 µl) solution of H-89, 2HCl (Cat. No. 371963) in DMSO.
      Hill FormulaC₂₀H₂₀BrN₃O₂S
      Chemical formulaC₂₀H₂₀BrN₃O₂S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationInSolution™ H-89, Dihydrochloride, CAS 127243-85-0, is a 10 mM solution of H-89, 2HCl in DMSO. A cell-permeable, potent, reversible, ATP-competitive inhibitor of protein kinase A (Ki = 48 nM).
      Biological Information
      Primary TargetPKA
      Primary Target K<sub>i</sub>48 nM against protein kinase A
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Irritant
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      371962-1MG 04055977213515