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504042 InSolution™ Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem

A 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl in H₂O.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Adriamycin, HCl, 14-Hydroxydaunomycin, HCl

504042
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      25316-40-9C₂₇H₂₉NO₁₁ · HCl
      Description
      Catalogue Number504042
      Brand Family Calbiochem®
      SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
      References
      ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
      Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
      Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
      Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
      Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
      Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
      O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
      Theyer, G., et al. 1993. J. Urol. 150, 1544.
      Tritton, T.R., and Yee, G. 1982. Science 217, 248.
      Product Information
      CAS number25316-40-9
      FormLiquid
      FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
      Hill FormulaC₂₇H₂₉NO₁₁ · HCl
      Chemical formulaC₂₇H₂₉NO₁₁ · HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      504042 0

      Documentation

      InSolution™ Doxorubicin, Hydrochloride - CAS 25316-40-9 - Calbiochem MSDS

      Title

      Safety Data Sheet (SDS) 

      References

      Reference overview
      A'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
      Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
      Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
      Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
      Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
      Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
      O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
      Theyer, G., et al. 1993. J. Urol. 150, 1544.
      Tritton, T.R., and Yee, G. 1982. Science 217, 248.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-March-2014 JSW
      SynonymsAdriamycin, HCl, 14-Hydroxydaunomycin, HCl
      DescriptionAn anti-tumor antibiotic and a highly effective myotoxin that inhibits topoisomerase II (IC50 = 100 nM). Binds to nucleic acids, presumably by specific intercalation into the DNA double helix, inhibiting nucleic acid synthesis. Cytotoxicity seems to be due to its ability to intercalate with DNA, interact with plasma membranes, and take part in oxidation-reduction reactions. Induces apoptosis in rhabdomyosarcoma cell lines.
      FormLiquid
      FormulationA 10 mM (5 mg/862 µL) sterile-filtered solution of Doxorubicin, HCl (Cat. No. 324380) in H₂O.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number25316-40-9
      Chemical formulaC₂₇H₂₉NO₁₁ · HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C or -70°C). Aliquots are stable for up to 3 months at -20°C or for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesA'Hern, R.P., and Gore, M.E. 1995.J. Clin. Oncol. 13, 726.
      Nooter, K., et al. 1995. Br. J. Cancer 71, 556.
      Noviello, E., et al. 1994. Mutat. Res.. 311, 21.
      Anderson, R.D., et al. 1993. Mutat. Res. 294, 215.
      Hershko, C., et al. 1993. J. Lab. Clin. Med. 122, 245.
      Jongmans, W., et al. 1993. Mutat. Res. 294, 207.
      O'Shaughnessy, J.A., and Cowan, K.H. 1993. J. Am. Med. Assoc. 270, 2089.
      Theyer, G., et al. 1993. J. Urol. 150, 1544.
      Tritton, T.R., and Yee, G. 1982. Science 217, 248.