189826 Sigma-AldrichInSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem
A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines.
More>> A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: Decitabine
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 2353-33-5 | C₈H₁₂N₄O₄ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
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| 189826-10MG |
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Glass bottle | 10 mg |
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| Description | |
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| Overview | A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available. |
| Catalogue Number | 189826 |
| Brand Family | Calbiochem® |
| Synonyms | Decitabine |
| Product Information | |
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| CAS number | 2353-33-5 |
| Form | Liquid |
| Formulation | A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO. |
| Hill Formula | C₈H₁₂N₄O₄ |
| Chemical formula | C₈H₁₂N₄O₄ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥ 98% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 189826-10MG | 04055977222050 |
Documentation
InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem MSDS
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InSolution™ 5-Aza-2ʹ-Deoxycytidine - CAS 2353-33-5 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 189826 |
References
| Reference overview |
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| Eggert, A., et al. 2001. Cancer Res. 61, 1314. Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun. 288, 921. Zhu, W.G., et al. 2001. Cancer Res. 61, 1327. Hopkins-Donaldson, S., et al. 2000. Cancer Res. 60, 4315. Haaf, T. 1995. Pharmacol. Ther. 65, 19. Jones, P.A., and Taylor, S.M. 1980. Cell 20, 85. |
Technical Info
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| White Paper - The Message in the Marks: Deciphering Cancer Epigenetics |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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