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377230 Hinokitiol

Hinokitiol MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-Isopropyltropolone, β-Thujaplicin

377230
  
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      Overview

      Replacement Information

      Key Spec Table

      CAS #Empirical Formula
      499-44-5C₁₀H₁₂O₂
      Description
      OverviewA cell-permeable, anti-microbial tropolone analog that acts as an effective chelator of Fe3+/Fe2+, Zn2+, and Mg2+. Serves as a metalloprotease inhibitor. Also acts as a reversible inhibitor of 12-lipoxygenase in platelets (IC50 = 100 nM). Reported to strongly inhibit the active respiration in isolated rat liver mitochondria. Inhibits DNA synthesis, induces differentiation and apoptosis in F9 embryonal carcinoma cells.
      Catalogue Number377230
      Brand Family Calbiochem®
      Synonyms4-Isopropyltropolone, β-Thujaplicin
      References
      ReferencesSuzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.
      Product Information
      CAS number499-44-5
      FormWhite solid
      Hill FormulaC₁₀H₁₂O₂
      Chemical formulaC₁₀H₁₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Target12-lipoxygenase in platelets
      Primary Target IC<sub>50</sub>100 nM
      Purity≥99% by GC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSGU4200000
      Safety Information
      R PhraseR: 22

      Harmful if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage REFRIGERATOR (+4°C)
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 2 months at -20°C; ethanol stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      377230 0

      Documentation

      Hinokitiol Certificates of Analysis

      TitleLot Number
      377230

      References

      Reference overview
      Suzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-August-2007 JSW
      Synonyms4-Isopropyltropolone, β-Thujaplicin
      DescriptionA cell-permeable, tropolone analog that exhibits anti-microbial properties. Acts as an effective chelator of Fe3+/Fe2+, Zn2+, and Mg2+ and induces differentiation in F9 embryonal carcinoma cells. Serves as an inhibitor of metalloproteases and 12-lipoxygenase (12-LO) in platelets (IC50 = 100 nM). Shown to inhibit active respiration in isolated rat liver mitochondria. Also reported to inhibit DNA synthesis and induce apoptosis.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number499-44-5
      RTECSGU4200000
      Chemical formulaC₁₀H₁₂O₂
      Structure formulaStructure formula
      Purity≥99% by GC
      SolubilityDMSO (20 mg/ml) or Ethanol (20 mg/ml)
      Storage Protect from light
      REFRIGERATOR (+4°C)
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°). DMSO stock solutions are stable for up to 2 months at -20°C; ethanol stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 9390
      ReferencesSuzuki, H., et al. 2000. Biochem. Biophys. Res. Commun. 275, 885. Tanaka, T., et al. 1999. Cell Biol. Int. 23, 541. Inamori, Y., et al. 1999. Biol. Pharm. Bull. 22, 990. Nakagawa, Y., and Tayama, K. 1998. Chem. Biol. Interact. 116, 45. Muto, N., et al. 1995. Biol. Pharm. Bull. 18, 1576. Bohme, G., et al. 1980. Acta. Biol. Med. Ger. 39, 1153.